关键词:

肝移植 , 他克莫司缓释胶囊 , 成人

Abstract:

Objective To explore the clinical application value of extended release tacrolimus in longterm adult liver transplantation recipients with stable liver function. Methods The clinical data of long-termliver transplant recipients who were followed up in our hospital from January 2018 to January 2023 and converted to extended release tacrolimus were reviewed. The changes of liver function，renal function，tacrolimus drug concentration and CD4+ T cell count at different time points before and after the application of extended release tacrolimus were analyzed. Results A total of 21 patients were treated with extended release tacrolimus after liver transplantation. The male to female ratio was 13 ∶ 8. The average age was（60.07±8.24）years old. The conversion time（from liver transplantation surgery）was（28.85±49.47）months. The dose ratio of immediate- and extendedrelease tacrolimus was 1 ∶ 1.03. Compared with that before conversion，the levels of alanine aminotransferase （ALT），aspartate aminotransferase（AST），γ-glutamyl transpeptadase（GGT），alkaline phosphatase（ALP）， creatinine（Cre），bloodureanitrogen（BUN），as well as the number of CD4+ T cells and tacrolimus concentration were not statistically significant in 2，4，12 weeks after dressing change. Three patients showed slight fluctuations in liver function，and liver function returned to normal after adding extended release tacrolimus. Conclusion The adult liver transplantation patients with stable liver function were changed from immediate tacrolimus to extended release tacrolimus，the liver function was stable and the rejection rate was low，the renal function was not significantly improved. 

Key words:

Liver transplantation, Extended release tacrolimus, Adult