关键词:

儿童 , 肺移植 , 终末期肺病

Abstract:

Objective To summarize the clinical experience of 12 children with lung transplantation. Methods We carried out a retrospective analysis on the data of 12 pediatric lung transplantation performedbetween December 2007 and August 2020，focusing on the indications，postoperative complications and survival rate. Results Twelve children underwent lung transplantation，including 5 males and 7 females. The age of patients were aged 2 to 17 years old at the time of lung transplantation（median age was 13.5 years old），and 5 cases were younger than 12 years old，accounting for 41.7%；their weight varies between 15 to 55kg（median weight was 45 kg）. According to the preoperative diagnosis，4（33.3%）had idiopathic pulmonary hypertension，3（25%） had bronchiolitis obliterans ，3（25%）had interstitial lung disease ，and 1（8.3%）had congenital heart disease and 1（8.3%）had pulmonary cystic fibrosis. The recipients all received lung grafts with identical or compatible ABO blood type. Cyclosporine or tacrolimus，mycophenolate mofetil and prednisone were applied as the immunosuppressive therapy. Postoperative complications included 10 cases of infection，3 cases of cardiac dysfunction，2 cases of primarygraft dysfunction，1 case of postoperative bleeding，and 1 case of airway stenosis. All patients recovered and were discharged after the operation. One patient died 6 months after the operation because of airway stenosis complicated with infection. Conclusion Lung transplantation is a safe and effective way to treat end-stage lung disease in children. We should pay more attention to selecting appropriate donors and recipients，standardizing operations，strengthening postoperative management and actively preventing complications in order to improve the survival rate of recipients.

Key words:

Children, Lung transplantation, End-stage lung disease