关键词:

 , 肺动脉高压 , 肺移植 , 机械通气时间 , 体外膜氧合时间

Abstract:

Objective To explore the effects of different pulmonary hypertension on mechanicalventilation time and extracorporeal membrane oxygenation （ECMO） of patients after lung transplantation. Methods A retrospective analysis was conducted on 101 patients with lung transplantation admitted to the Department of Critical Care Medicine，Wuxi People's Hospital Affiliated to Nanjing Medical University from June 2nd，2018 to May 5th，2020. According to the different degrees of pulmonary hypertension after lung transplantation，the patients were divided into 62 patients with mild pulmonary hypertension group（≤ 49 mmHg，1 mmHg ＝ 0.133 kPa）and 39 patients with moderate and severe pulmonary hypertension group（≥ 50 mmHg）. Cox proportional risk model was used to analyze the effects of pulmonary hypertension on mechanical ventilationtime and ECMO after lung transplantation. The 30 d Kaplan-Meiers survival curve was used to analyze theeffects of different pulmonary hypertension groups on ECMO time and mechanical ventilation time of patients after lung transplantation. Results There were significant differences in age，primary disease，pulmonary hypertension value，ECMO mode and hemoglobin between mild and moderate to severe pulmonary hypertension groups （P ＜ 0.05）. The mechanical ventilation time and ECMO time of the two groups were compared according to the 30 d postoperative survival（P ＜ 0.05）. Univariate Cox regression analysis showed that the mechanical ventilation time and ECMO time of the two groups had statistically significant effects on the survival time after lung transplantation. Multivariate Cox regression analysis showed that the effect of mechanical ventilation time on survival time of patients after lung transplantation was statistically significant. Conclusion Patients with moderate and severe pulmonary hypertension after lung transplantation need longer ECMO time and mechanical ventilation time. 

Key words:

Pulmonary hypertension, Lung transplantation, Mechanical ventilation time, ECMO time