Objective To evaluate the effect of intravenous insulin pump on early hyperglycemia after liver transplantation, so as to provide a basis for the standardized management of early hyperglycemia after liver transplanta tion. Methods Retrospective analysis was performed on the effect of intravenous insulin pump on the management of early hyperglycemia after liver transplantation in patients who underwent liver transplantation from October 2018 to August 2019 and the impact on the related postoperative indicators. According to whether standardized intravenous insulin pump management was implemented, the patients were divided into two groups: the control group（n ＝ 40）, and the group without standardized intravenous insulin pump management from October 2018 to March 2019. Observation group（n ＝ 40）. The standardized intravenous insulin pump management group was implemented from March to August, 2019. That is, according to the patient's medical history and blood glucose situation, the treatment plan of the intravenous insulin pump was jointly developed by doctors and nurses, and the nurse conducted dynamicquantitative monitoring and adjustment according to the patient's blood glucose level. The blood glucose level 2 hours before and after diet and before and after sleep, the time when blood glucose was normal after surgery, daily insulin intake, wound healing degree and recovery time in the same period, the number of patients with re-infection, the number of cases of hypoglycemia and other indicators were counted. Results Postoperative hyperglycemia control effect in hospitalized liver transplantation patients was significantly better in the observation group than in the control group, with statistically significant difference（P ＞ 0.5）. Conclusion The standardized intravenous insulin pump treatment can better control patients' hyperglycemia, reduce blood glucose fluctuations and effectively reduce the incidence of hypoglycemia, etc.. This strategy is better than the conventional intravenous insulin pump treatment and it is worth of clinical application.