Objective To discuss the practice and effectiveness of the multidisciplinary team model led by specialized nurses in the post-surgery management of adult DCD kidney transplantation. Methods A retrospective study was performed in our center from September 2017 to August 2018 including 118 cases of adult renal transplant patients. The control group was given routine nursing，while the observation group received the MDT management led by specialized nurses. We recorded the nursing quality as well as the complications such as the catheter related complications and nursing related symptoms. Results The observation group suffered from lower incidence of catheter related complications（PICC catheter，central venous catheter，peritoneal dialysis catheter，P ＜ 0.05）， fewer and milder incident of the main complications and had a higher nursing quality score（primary care ，early warning of complications，infection control，health education，and patients satisfaction）than those of control group after renal transplantation（P ＜ 0.05）. Conclusion The MDT mode led by specialized nurses in the management of adult DCD kidney transplantation played a promising role in reducing nursing related complications，improving patient recovery and promoting the clinical nursing quality.