关键词:

淋巴细胞亚群 , 肺移植 , 矽肺 , 百草枯

Abstract:

Objective To investigate the application value of dynamic monitoring of lymphocyte subsets （including T，B and NK cells）after lung transplantation. Methods Flow cytometry was used to dynamically monitor the changes of lymphocyte subsets at different time points before and after lung transplantation in two patients. Results Two recipients presented different changes of lymphocyte subsets before and after lung transplant. The preoperative lymphocyte subsets were in normal level in one recipient，the T lymphocyte subgroup returned to reference range nine days after transplant，the absolute number of NK cells remained low，the CD4/CD8 level first increased and then decreased postoperatively in this patients. The lymphocyte subsets has been restored to normal levels 6 month after transplant. In case 2，the lymphocyte subsets were severely reduced before surgery，and the absolute number of CD3+CD8+ T lymphocytes returned to normal level 7 days after surgery. CD3+CD4+ T lymphocytes and CD4/CD8 remained low，while NK cells and B cells fluctuated slightly and were below the reference range at most time points. Conclusion Dynamic monitoring of lymphocyte subsets after lung transplantation cantimely evaluate the immune status of patients，provide reference for individualized diagnosis and treatment and timely adjustment of medication regimen. 

Key words:

Lymphocyte subsets, Lung transplantation, Silicosis, Paraquat