关键词:

肺移植 , 肺纤维化 , 肺功能 , 并发症

Abstract:

Objective The clinical effects of single lung transplantation （SLT）and bilateral lung transplantation（BLT）in the treatmentof end-stagepulmonaryfibrosiswere compared to provide a reference for the choice of clinical treatment. Methods Retrospectiveanalysisofpatients withpulmonaryfibrosis who underwent lung transplantation at Wuxi People's Hospital affiliated to Nanjing Medical University between February 2020 and December 2020 was performed，a total of 72 patients were included，and were divided into two groups based on the type of surgery, including single-lung transplantation group（24 cases）and bilateral-lung transplant transplantation group（48 cases）. Preoperative characteristics，intraoperative conditions，functional improvement andpostoperative complications between the two groups were analyzed retrospectively. Results TheageinSLT groupwas significantly older than the BLT group〔65（57，69.75）years vs 55（48，61.75）years，P ＜ 0.05〕，which was in consistent with the fact that single lung transplantation was mostly performed in the elderly patients in this center. The two groups were comparable in other preoperative clinical data（P ＞ 0.05）. The predicted value of FVC% and FEV1% in the BLT group were better than those in the SLT group（P ＜ 0.05）. However the cold ischemia timeand total operation time were shorter in the SLT group than in the BLT group，and the intraoperative blood loss was less in SLT group than that in the BLT group（P ＜ 0.05）. There were no significant differences between the twogroups in the incidence of bronchial stenosis，bronchial stenosis，bronchial stenosis and primary graft dysfunction （P＞0.05）. Conclusion BLT has advantages in treating patients with end-stage pulmonary fibrosis and can effectively improve postoperative lung function，but SLT should still be considered in some selected patients. 

Key words:

Lung transplantation, Pulmonary fibrosis, Spirometry, Complication