关键词:  , 肾移植术后 ； IgAN 复发 ； 危险因素

Abstract:

Objective To investigate the risk factors of IgA nephropathy recurrence after kidney transplantation. Methods A total of 149 kidney failure patients with primary IgA nephropathy who received kidney transplantation at the Organ Transplantation Center of Zhengzhou People's Hospital from January 2008 to December 2019 were selected as the study subjects. According to the results of the protocol kidney biopsy，the recipients were divided into the recurrent group（40 cases）and the non-recurrent group（109 cases）. Gender，age，donor type，dialysis duration，progression to end-stage renal disease（ESRD），history of transplantation，historyof hypertension and diabetes，history of postoperative infection，immunosuppressive regimen，HLA mismatchnumber，and risk factors for postoperative recurrence were recorded in the two groups. Results Compared withthe non-recurrent group，there were no statistically significant differences in gender，number of kidney transplants，diabetes，hypertension，immunosuppressive regimen，postoperative infection history，dialysis time between the two groups（P ＞ 0.05）. Logistic analysis showed that donor origin，recipient age and HLA mismatch were the risk factors for IgAN recurrence after renal transplantation，and the differences were statistically significant（All P ＜ 0.05）. Conclusion The recurrence of IgA nephropathy after kidney transplantation was related to the source of donor，recipient age and HLA mismatch. Intervention measures should be taken according to the above factors to provide ideas for clinical control of IgAN recurrence. 

Key words: Post-renal transplantation, Recurrence of IgAN , Risk factors