肾移植 , 免疫抑制剂 , 服药依从性 , 护理干预

Objective To investigate factors affecting medication adherence of patients who take immunosuppressive agents after kidney transplantation and to evaluate the effectiveness of specific nursing interventions. Methods A questionnaire survey was conducted in patients and nurses to find out the factors that affect medication compliance，and targeted nursing intervention methods were proposed. A total of 100 renal transplant patients in 2017 were collected and divided into intervention group and control group. The intervention group were subdivided into 4 groups，3 received single intervention seperately，the comprehensive intervention group received all of the intervention. The effect were evaluated with modified Morisky Medication Adherence Evaluation Scale，and the results were just good or not good. Chi-square test was used to analyze difference between groups. Results Factors that affect medication adherence were：① insufficient knowledge about the importance of taking medicine under order. ② Problem concerning medicine management. ③ Inadequate management of patients after discharge. Rate of good adherence in all intervention groups was 84%，that is higher than 60% in the control group（P ＜ 0.05）. The rate of good adherence in comprehensive intervention group was 91.3% which was significantly higher than the control group （P ＜ 0.05）. Comparison between other groups didn’t show any statistical difference. Conclusion Our studyexplored several important factors that affect medication adherence of patients who take immunosuppressive agents after kidney transplantation. Interventions focusing on these factors improve medication adherence. Comprehensive intervention was more effective than applying single intervention method

Kidney transplantaion, Immunosuppressor, Medication adherence, Nursing intervention