肾移植 , 细菌 , 耐药性

Objective The specific situation of bacterial resistance after kidney transplantation in a hospital during 2016 — 2018 was analyzed to provide reference for the empirical drug selection on bacterial infection after kidney transplantation in the First Affiliated Hospital，Sun Yat-sen University. Methods The bacterial drug resistance of 367 suspected infected patients in the kidney transplantation during 2016 — 2018 was retrospectively analyzed，including the distribution of bacterial etiology and the change of drug resistance. Results A total of 400 strains of bacteria were isolated in the patients after renal transplantation，among which 226 strains of gramnegative bacteria（56.50%）and 174 strains of gram-positive bacteria（43.50%）were isolated. The top four gramnegative bacteria were 61 strains of escherichia coli（15.25%），51 strains of klebsiella pneumoniae（12.75%）， 31 strains of pseudomonas aeruginosa（7.75%），and 20 strains of acinetobacter baumandii（5%）. The top four grampositive bacteria were 59 strains of coagulase negative staphylococcus（14.75%），44 strains of enterococcus faecalis （11%），39 strains of enterococcus faecalis（9.75%）and 20 strains of staphylococcus aureus（5%），respectively. No carbapene-resistant escherichia coli was found，and klebsiella pneumoniae showed an increasing trend of resistance to carbapenenase，while non-fermentation bacteria showed relatively high resistance to carbapenenase. Vancomycin was highly sensitive to staphylococcus. Conclusion Escherichia coli and klebsiella pneumoniae were the main infections in patients after renal transplantation. When empirically selecting antimicrobial agents，it is necessary toconsider the drug resistance of the above pathogenic bacteria，and timely adjust the drug regimen according to the drug sensitivity report. Combined drug use may be considered for multidrug-resistant bacteria.

Renal transplant, Bacterium, Drug resistance