肾移植 , 生物免疫诱导剂 , 抗人 T 细胞兔免疫球蛋白 , 巴利昔单抗

Objective To investigate and compare the effects of two kinds of biological immune inducers， anti-human T-cell rabbit immunoglobulin（ATG）and baliximab，on inflammatory markers such as C reactive protein （CRP）and procalcitonin（PCT）after kidney transplantation. Methods The data of 115 renal transplant patients treated with ATG or baliximab from January 2016 to December 2016 were retrospectively analyzed. The levels of CRP and PCT in the three stages of 1 ～ 4 days，5 ～ 7 days and ＞ 7 days after renal transplantation were compared and analyzed.. Results CRP and PCT in both groups increased at first and then returned to normal after renal transplantation. Regarding the impact of CRP，ATG group caused higher CRP than baliximab group in the stage of 1 ~ 4 day（P ＜ 0.05），and there was no significant difference in recovery time between the two groups（P ＞ 0.05）. When comparing with baliximab group，there were significant differences in PCT value at each stage after transplantation in ATG group（P ＜ 0.001）. There was also significant difference in the time of normalization between the two groups,（9.2 ± 3.8）days and（4.1 ± 2.5）days, respectively. Conclusion In renal transplantation， PCT was significantly increased in ATG group and its recovery time was prolonged. The effect of biological immune inducers on inflammatory markers must be considered in perioperative evaluation of infection and rejection in renal transplantation.