实用器官移植电子杂志

实用器官移植电子杂志 ›› 2019, Vol. 7 ›› Issue (6): 464-468.DOI: 10.3969/j.issn.2095-5332.2019.06.014

• 论著 • 上一篇    下一篇

供体高钠血症对肝移植术后肝功能早期恢复的影响

于潇，张雯，郑清元，崔红磊，王森岩，卫凌华，郭文治
  

  1. 郑州大学第一附属医院肝胆胰外科，河南省消化器官移植重点实验室，河南省器官移植医学工程技术中心，河南 郑州 450052
  • 出版日期:2019-11-20 发布日期:2021-06-02
  • 基金资助:

    国家自然科学基金资助项目（81671958，U1604282）；

    河南省高校创新人才项目（19HASTIT003）；

    河南省卫计委医学科技攻关计划项目（SBGJ2018023）

Effect of donor hypernatremia on early recovery of liver function after liver transplantation

Yuxiao，Zhangwen，Zheng Qingyuan，Cui Honglei，Wang Senyan，Wei Linghua，Guo Wenzhi.
  

  1. The Departmen ofHepatobilary and Pancreatic Surgery，the First Affiliated Hospital of Zhengzhou University，Henan Provincial Key Laboratoryof Digestive Organ Transplantation，Henan Organ Transplant Medicine Engineering Technology Center，Zhengzhou
    450052，Henan，China
  • Online:2019-11-20 Published:2021-06-02

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摘要：

目的 探究供体获取前高钠血症对受体移植术后早期恢复是否存在影响。方法 采用回顾性研究的方法，收集 2016 年 1 月—2018 年 12 月在郑州大学第一附属医院行肝移植手术的 118 例患者的临床资料，按照受体术前原发病（肝癌组与非肝癌组）分为两组，根据术前血钠浓度分为正常组（＜ 160 mmol/L）和高钠血症组（＞ 160 mmol/L），分析各组术前终末期肝病模型（model for end stage liver disease，MELD）评分、天冬氨酸转氨酶（aspartate transaminase，AST）、丙氨酸转氨酶（alanine aminotransferase，ALT）、总胆红素（totalbilirubin，TB）等及术后 AST、ALT、TB 和术后重症监护病房（intensive care unit，ICU）住院时间等方面是否有差异，明确供体获取前高钠血症对肝移植术后受体早期恢复的影响。结果 无论在肝癌组还是非肝癌组受体术前、术中情况均无统计学差异，术后第 1、3、5、30、90 d 肝功能，术后第 30、90 d 肝功能恢复程度及术后 ICU 住院时间和术后总住院时间等方面均无统计学差异。结论 供体获取前高钠血症对受体肝移植术后早期恢复无显著影响。

关键词:

Abstract:


Objective To investigate whether pre-procurement donor hypernatremia affects early graft recovery after liver transplantation. Methods A retrospective study was conducted by collecting the clinical data of 118 patients undergoing liver transplantation at the First Affiliated Hospital of Zhengzhou University from January 2016 to December 2018. According to the preoperative primary disease，the recipients were divided into hepatocellular carcinoma group and non-hepatocellular carcinoma group. The recipients were divided into normal blood sodium concentration group（＜ 160 mmol/L）and hypernatremia group（＞ 160 mmol/L）according to the preoperativeblood sodium concentration in donors. The difference in model for end stage liver disease（MELD）score，aspartatetransaminase（AST），alanine aminotransferase（ALT），total bilirubin（TB）and other postoperative AST，ALT，TB and postoperative intensive care unit（ICU）and hospitalization time were analyzed. The effects of donor hypernatremia on early recovery of recipients after liver transplantation were analyzed. Results There was no statistical difference between the liver cancer group and the non-hepatocellular carcinoma group before and during the operation. There were no significant differences in liver function at 1 st，3 rd，5 th，30 th and 90 th postoperatively days in two groups. The liver function recovery at the 30 th and 90 th postoperative days，postoperative ICU stay and total hospital stayshowed no significant differences in two groups. Conclusion Donor hypernatremia before donor procurement hadno significant effect on early recipient recovery after liver transplantation。


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