关键词: 肝细胞癌 , 肝移植 , 复发 , 综合治疗

Abstract:

Objective To discuss the experience of diagnosis and treatment for the patients with recurrenthepatocellular carcinoma （HCC） long-term after liver transplantation. Methods The clinical data were retrospectively analyzed from 1 308 HCC patients who received liver transplantation from April 2001 to September 2018 in Liver Cancer Institute, Fudan University. Close laboratory examination and radiological follow-up wereperformed post-transplantation. Results There were 2 patients with metastasis of HCC 10 years after liver transplantation. The patients' condition was satisfactorily controlled by comprehensive treatment strategy and one patient got complete response. Conclusion LT is one of the radical treatments for HCC, however，tumor recurrence and metastasis remain the most important factors that affect the outcome of liver transplantation. Screening the recipients properly, selecting the sensitive factors which can accurately predict the prognosis after liver transplantation,offering effective intervention for patients at high risks of recurrence and providing individualized treatment after recurrence and metastasis may further improve the outcome of LT with HCC.

Key words: Hepatocellular carcinoma, Liver transplantation, Recurrence, Comprehensive treatment