肝移植 , 感染 , CD4+T 淋巴细胞 , 三磷酸腺苷

Objective To investigate the relationship between the CD4+T lymphocytes ATP level inperipheral blood and infections after liver transplantation（LT）. Methods Total 142 samples were collected from101 patients' peripheral blood post-LT. CD4+T lymphocytes ATP value was analyzed by ImmuKnow immune cellfunction assay kits. According to the occurrence of infection and immune responses conditions，the patients post-LTwere divided into different groups and then the relationship between the level of CD4+T cells ATP and infection wasanalyzed. Results According to the clinical state，the patients were divided into infection group and non-infectiongroup. CD4+T lymphocytes ATP value was significantly different between the two groups（P ＝ 0.001），which were236.0（41.0～512.0）μg/L and 371.5（9.0～1000.0）μg/L respectively. On the other hand，the patients post-LT weredivided into low immune response group，normal immune response group and high immune response according to the ATP levels of CD4+T lymphocytes in peripheral blood. The infection rates were 25.0%，13.6% and 0 in these groupsrespectively，which had significant statistic difference among three groups（P ＝ 0.003）. Conclusion The ATP value of CD4+T lymphocyte in peripheral blood was significantly correlated with occurrence of infection post-LT whichwould be helpful to conduct clinical therapy.

Liver transplantation, Infection, CD4+T lymphocyte, ATP