Objective To offer rational of blood transfusion during liver transplantation by an analysis of perioperative blood transfusion in 132 patients with liver transplantation. Methods The blood transfusion in 132 liver transplantation patients from 2013 to 2017 were researched retrospectively，the effect of preoperative laboratory parameters and diverse primary diseases on perioperative blood transfusion in patients with liver transplantation were studied. The relationship was analyzed between perioperative blood transfusion and preoperative laboratory parameters. The amount difference of intraoperative blood transfusion was compared between groups of different primary diseases. Results The frequency of blood transfusion of 132 patients with preoperative，intraoperative and postoperative liver transplantation were 10%，100% and 98% respectively，the ratio of red blood cell and plasma were 1.94 : 1，0.63 : 1 and 0.27 : 1，and the results showed that the amount of intraoperative blood transfusesion was associated with factors including direct bilirubin，total bilirubin，hemoglobin，activated partial thromboplastin time， thrombin time and thromboela-stogram results. Conclusion The primary disease and preoperative laboratory index of patients with liver transplantation should be considered，and the blood ingredients could be prepared properly before operation to guarantee the operation would get on well and to avoid the waste of blood at the same time.