Objective To explore the effects of cluster nursing in prevention and treatment of perianal dermatitis in patients with diarrhea after liver transplantation. Methods A total number of 94 cases with diarrhea after liver transplantation were randomly divided into control group and observation group, with 47 cases in each group. Routine nursing procedure was adopted in the control group and cluster nursing intervention was given to the observation group. The incidence, severity and recovery time of perianal dermatitis in the two groups were compared. Results Comprehensive special management was carried out by cluster nursing, including preevaluation and examination, early intervention nursing, standard management of perianal skin cleaning, construction of local skin barrier, strengthening of special inspection scope and improvement of nursing execution. In the observation group with cluster nursing, the incidence and severity of perianal dermatitis were significantly lower than that of the control group（P ＜ 0.05）, and the recovery time of perianal dermatitis was significantly shortened （P ＜ 0.05）. Conclusion The application of cluster nursing measures can effectively reduce the occurrence and severity as well as promote the early recovery of perianal dermatitis in patients with diarrhea after liver transplantation.