Objective To investigate the quality of life after liver transplantation and its influencing factors. Methods From December 2017 to January 2018，a total number of 117 cases of liver transplant recipients who participated in the 7th organ transplantation exchange meeting as well as follow-up visits in the first affiliated hospital of Sun Yat-sen University were included in the study. The present life quality was analyzed using general questionnaire and the World Health Organization quality of life questionnaire. Multiple linear regression method is applied to analyze the factors affecting the quality of life in liver transplant recipients. Results The average grade of life quality in 117 cases of liver transplant recipients of this study was（209.3±56.6）scores，the average physical field scoring was（52.7±18.0）scores，the average psychological field scoring was（51.8±18.8）scores， the average score for social relations field was（51.9±16.5）scores，the average environmental scoring was（50.1± 16.9）scores. The scoring of all four areas was lower than the normal population，in addition to the environmental area，the difference was statistically significant（P < 0.05）. Conclusion The quality of life of liver transplantation recipients is mainly affected by marital status，postoperative survival time，postoperative complications，postoperative employment and irregular follow-up etc. Medical staff should pay more attention and help the liver transplantation recipients improve their quality of life.