Objective To explore the clinical effect of perioperative nursing on modified ipsilateral simultaneous pancreas and kidney transplantation. Methods From September 2016 to December 2018， 64 patients who underwent ipsilateral simultaneous pancreas and kidney transplantation with modified operation in the Organ Transplantation Center of the Second Affiliated Hospital of Guangzhou Medical University were analyzed. The main points of perioperative nursing were discussed. Results 64 patients achieved good clinical results. The serum creatinine levels at 1，3，6，12 and 24 months after operation were（119.85±51.39）μmol/L，（114.38± 43.78）μmol/L，（115.42±44.62）μmol/L，（110.96±28.94）μmol/L，（112.48±34.57）μmol/L，fasting blood glucose were（5.63±1.38）mmol/L，（4.80±0.45 mmol/L，（4.95±0.66）mmol/L，（4.80±0.56）mmol/L，（4.82±0.53）mmol/L. The cumulative survival rates of recipient, pancreas and kidney in one year and two years were 94.4%，92.9%，92.9% and 94.4%，92.9% and 92.9%，respectively. One patients underwent pancreatectomy due to pancreaticoduodenal leakage caused by pancreatic rejection and sepsis; one patient due to pancreatic thrombosis after transplantation. The other patients recovered well in terms of pancreatic function，and blood sugar could be reduced to normal level at 2 to 3 days after operation，insulin could be completely withdrawn after operation. One case had delayed recovery of renalallograft function，one case had renal allograft failure，the rest of the recipients recovered well. Conclusion The nursing experience on 64 cases of simultaneous pancreas and kidney transplantation summarized in our center has certain significance of guidance and reference for clinical nursing.