关键词:

text-indent:0pt, vertical-align:middle, "> 肝移植, 肝性脊髓病, 功能恢复

Abstract:

Objective To evaluate the long-term efficacy and neurological outcomes of liver transplantation in patients with decompensated liver cirrhosis complicated by hepatic myelopathy. Methods This single-center retrospective case analysis included 9 patients with decompensated liver cirrhosis and hepatic myelopathy who underwent liver transplantation at Tianjin First Central Hospital between January 2014 and March 2025 and were followed up long-term. Baseline characteristics，surgical data，and follow-up information were collected. Neurological disability and activities of daily living were assessed using the modified rankin scale（MRS）and the Modified Barthel Index（MBI），respectively. The Wilcoxon signed-rank test was employed to compare score differences before and after surgery. Results All 9 male patients were followed up，with a mean age of（46 .8 ±7.8）years. At the final postoperative follow-up，the median MRS score was significantly lower than the preoperative score〔3 .0（2 .0，4.0）vs.4.0（4 .0～4.0），P＝0.034〕. The median MBI score was hig her than the preoperative level〔92 .0（85 .0～100.0） vs. 86.0（58 .0～87.0），P＝0.075〕；although this difference did not reach statistical significance，it indicated a clear trend towards improvement. Case analysis suggests that patients with a shorter disease course may benefitmore. Conclusion Liver transplantation can significantly improve neurological disability in patients with hepatic myelopathy and shows a trend towards enhancing their activities of daily living，proving to be an effective treatment for myelopathy and shows a trend towards enhancing their activities of daily living，proving to be an effective treatment for this condition. Early intervention with liver transplantation may lead to optimal neurological outcomes.

Key words:

text-indent:0pt, vertical-align:middle, "> Liver transplantation, Hepatic myelopathy, Recovery of function