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2025, 13 (3): 269-273. DOI: 10.3969/j.issn.2095-5332.2025.03.017
Abstract39)      PDF (799KB)(12)      
Analysis of the efficacy of vascular interventional therapy for transplanted renal artery stenosis  
Li Shuxin, Zhao Yongheng, Chen Wenzhong, Hu Wei, Zhou Yunchong, Song Yonglin, Ma Yinrui, Sun Xun.
2020, 8 (2): 106-109. DOI: 10.3969/j.issn.2095-5332.2020.02.007
Abstract233)      PDF (2529KB)(109)      
Objective To investigate the effect of vascular interventional therapy on transplanted renal arterial stenosis(TRAS). Methods The patients with concurrent TRAS among 513 patients with renal transplantation were retrospectively enrolled. The changes of creatinine,blood pressure and hemodynamic index of transplanted renal hemography in patients 1 week,1 month,3 months,and 6 months after treatment were compared. Results Of the 513 patients with kidney transplantation,9 experienced concurrent TRAS,with an incidence rate of 1.75%. The 9 patients were treated with vascular interventional treatment,8 patients received simple balloon expansion and 1 patient was implanted with vascular stents after balloon expansion. In patients with cystic dilation,3 cases recurred within 2 months of surgery,with a secondary stenosis rate of 33.3%,and the secondary cystic dilation was successful. All patients were followed up for 6 months,and one patient died of lung infection 4 months after vascular intervention therapy. Blood creatinine in pre-treatment patients was(142.3±59.6)μmol/L,and were (133.5±57.2)μmol/L,(131.8±35.6)μmol/L,(127.0±29.9)μmol/L,(125.7±37.1)μmol/L at 1 week,1 month, 3 months,6 months after treatment,respectively. Although there is no statistical difference,there is a downward trend after treatment. Pre-treatment systolic pressure was(149.7±19.3)mmHg(1 mmHg = 0.133 kPa),the value were(131.3±4.1)mmHg,(136.2±7.9)mmHg,(128.5±6.6)mmHg,(127.1±3.6)mmHg at 1 week,1 month,3 months,6 months after treatment. Systolic pressure was significantly reduced compared with pre-treatment level. The Pre-treatment transplanted renal aortic peak systolic velocity(PSV)was(297.2±105.3)cm/s,the velocity were (171±56.3)cm/s,(185.8±64.8)cm/s,(197.5±69.1)cm/s,(178.8±75.4)cm/s at 1 week,1 month,3 months, 6 months after treatment, There are statistical differences compared with pre-treatment. The interfolate arterial PSV, interfolate artery resistance index were similar at 1 week,1 month,3 months,6 months after treatment compared to preoperative levels. Conclusion Vascular interventional therapy is effective in improving the transplanted kidney function of TRAS patients.
Research hotspots and trends of artificial intelligence in organ transplantation
Lin Xiaohong , Jia Yingtian , Liu Hongxia , Ding Zhenshan .
2025, 13 (6): 489-496. DOI: 10.3969/j.issn.2095-5332.2025.06.002
Abstract15)      PDF (2735KB)(10)      

Objective To analyze the research hotspots and development trends of artificial intelligencein the field of organ transplantation. Methods Literatures on the application of artificial intelligence inthe field of organ transplantation from January 2004 to June 2024 were retrieved from the Web of ScienceCore Collection and China National Knowledge Infrastructure database. CiteSpace 6.2.R6 software was used for visual analysis. Results A total of 728 relevant literatures were retrieved559 English literatures and 143 Chinese literatures were included after screening. The number of literatures published in the early stage was small,while the number of literatures published in recent years has increased significantly. The country with the largest number of articles was the United States,followed by China. The top three institutions in terms of foreignpublications were Mayo Clinic,University of Toronto and Harvard University. Zhejiang University,Peking UnionMedical College and the First Affiliated Hospital of Sun Yat-sen University were the most active institutions in China. The authors who have published the most articles in English were Cheungpasitporn Wisit and Thongprayoon Charat,and the author who has published the most articles in Chinese was Ren Bin. The main high-frequency keywords in English were machine learning,survival,artificial intelligence,liver transplantation,kidney transplantation,mortality,risk,model,outcome and deep learning. The main high-frequency keywords in Chinese were machine learning liver transplantation kidney transplantation deep learning artificial intelligence hepatocellular carcinoma,radiomics,liver cancer,prognosis and tacrolimus. The first emergent keywords in English were artificial neural networks,data mining and survival analysis,and the most recent were predictive model and kidney transplant. The first emergent keywords in Chinese were neural networks,cyclosporine A,and blood concentration,and the most recent were deep learning and machine learning. Conclusion The application of artificial intelligence in thefield of organ transplantation is increasing significantly. The use of machine learning and deep learning to construct prediction models and to analyze the survival of various organ transplantation patients is a current research hotspots. In the future,exchanges and cooperation between countries and disciplines can be strengthened to promote the study and application of advanced AI technologies,so as to further promote the development of this field. 

2022, 10 (2): 146-146. DOI: 10.3969/j.issn.2095-5332.2022.02.010
Abstract312)      PDF (684KB)(612)      
2024, 12 (1): 93-96. DOI: 10.3969/j.issn.2095-5332.2024.01.020
Abstract81)      PDF (673KB)(23)      
2015, 3 (2): 74-78.
Abstract49)      PDF (785KB)(346)      
The effect of the holistic care on the quality of life in patients with postoperative infection after kidney transplantation
Ding Mei.
2019, 7 (2): 109-112. DOI: 10.3969/j.issn.2095-5332.2019.02.005
Abstract155)      PDF (2450KB)(111)      

Objective To explore the effect of the holistic care on the quality of life assessment systemin patients with postoperative infection after kidney transplantation. Methods The clinical data of 92 patients with infection after renal transplantation in our hospital from January 2017 to December 2017, were analysed retrospectively. The patients were divided into nursing group(observation group)and routine nursing(controlgroup),according to different nursing plans,each group has 46 patients. The nursing quality were compared between the two groups,mainly on the scores of the nursing quality,survival quality score,anxiety score,compliance evaluation,physical comfort,environmental comfort ratings,and patient satisfaction. Results The comprehensive nursing quality(education,nursing attitude,nursing skills,ward management)in the observation group were significantly higher than that in the control group,and the difference were statistically significant(χ2 = 14.286,P = 0.003 ;χ2 = 16.331,P = 0.003 ;χ2 = 19.247,P = 0.002 ;χ2 = 18.295,P = 0.003). The survival quality score in the observation group was significantly higher than that in thecontrol group,and the difference was statistically significant(t = 4.672,P = 0.002). Anxiety scores in the observation group were significantly lower than that in the control group,and the difference was statistically significant(t = -4.855,P = 0.003).The compliance score,physiological comfort score and environmental comfortscore in the observation group were significantly higher than those in the control group,and the difference werestatistically significant(t = -19.218,P = 0.002 ;t = -14.821,P = 0.003 ;t = -16.115,P = 0.002).Nursing satisfaction in observation group was significantly higher than that in control group,and the difference was statistically significant(χ2 = 4.873,P = 0.001)Conclusion “The holistic care”intervention could reduce the psychologicalburden of patients and their families as well as relieve the pain on the body,mind and spirit in all aspects. This method could also improve the quality of patients' lives along with the quality of nursing work. It has important guidingsignificance for clinical management of infection after renal transplantation and related nursing work.

2022, 10 (4): 301-308. DOI: 10.3969/j.issn.2095-5332.2022.04.003
Abstract302)      PDF (741KB)(934)      
2024, 12 (5): 433-438. DOI: 10.3969/j.issn.2095-5332.2024.05.012
Abstract48)      PDF (1089KB)(21)      
2022, 10 (4): 380-384. DOI: 0.3969/j.issn.2095-5332.2022.04.019
Abstract77)      PDF (721KB)(40)      
2018, 6 (4): 307-. DOI: 10.3969/j.issn.2095-5332.2018.04.012
Abstract68)      PDF (654KB)(27)      
Investigation on factors affecting medication adherence after renal transplantation and the effect of nursing intervention
Li Wen, Hua Yan.
2020, 8 (2): 110-114. DOI: 10.3969/j.issn.2095-5332.2020.02.008
Abstract147)      PDF (2846KB)(83)      
Objective To investigate factors affecting medication adherence of patients who take immunosuppressive agents after kidney transplantation and to evaluate the effectiveness of specific nursing interventions. Methods A questionnaire survey was conducted in patients and nurses to find out the factors that affect medication compliance,and targeted nursing intervention methods were proposed. A total of 100 renal transplant patients in 2017 were collected and divided into intervention group and control group. The intervention group were subdivided into 4 groups,3 received single intervention seperately,the comprehensive intervention group received all of the intervention. The effect were evaluated with modified Morisky Medication Adherence Evaluation Scale,and the results were just good or not good. Chi-square test was used to analyze difference between groups. Results Factors that affect medication adherence were:① insufficient knowledge about the importance of taking medicine under order. ② Problem concerning medicine management. ③ Inadequate management of patients after discharge. Rate of good adherence in all intervention groups was 84%,that is higher than 60% in the control group(P < 0.05). The rate of good adherence in comprehensive intervention group was 91.3% which was significantly higher than the control group (P < 0.05). Comparison between other groups didn’t show any statistical difference. Conclusion Our studyexplored several important factors that affect medication adherence of patients who take immunosuppressive agents after kidney transplantation. Interventions focusing on these factors improve medication adherence. Comprehensive intervention was more effective than applying single intervention method
2021, 9 (5): 386-389. DOI: 10.3969/j.issn.2095-5332.2021.05.011
Abstract85)      PDF (702KB)(75)      
2022, 10 (6): 503-506. DOI: DOI:10.3969/j.issn.2095-5332.2022.06.005
Abstract75)      PDF (982KB)(4)      
2025, 13 (1): 1-6. DOI: 10.3969/j.issn.2095-5332.2025.01.001
Abstract59)      PDF (1006KB)(58)      
2025, 13 (1): 67-72. DOI: 10.3969/j.issn.2095-5332.2025.01.016
Abstract72)      PDF (790KB)(27)      
Analysis on the treatment of patients with acute respiratory distress syndrome caused by cytomegalovirus pneumonia after renal transplantation
Shi Yanming, Shi Linyu, Wang Jianning.
2014, 2 (3): 150-152. DOI: 10.3969/j.issn.2095-5332.2014.03.004
Abstract138)      PDF (1702KB)(74)      

Objective To study the treatment of patients with acute respiratory distress syndrome(ARDS caused by cytomegalovirus(CMV)pneumonia after renal transplantation. Methods A retrospective analysis of21 patients with ARDS caused by CMV pneumonia after renal transplantation in 4 years in the hospital was doneThe general situation,treatment and clinical outcomes were summarized and analyzed. All the 21 patients were treated with antiviral therapy,decreased the dosage of immunosuppressant,supported with active whole body supporttherapy,and applied with timely ventilation. Results In the 21 patients,the treatment of 16 cases was effectiveThree cases experience respiratory failure and died after active treatment. Two cases died after discharge not suggested by medical staff. The effective rate was 76.19%. All CMV antigen in peripheral blood turned negative after treatment. Of the 16 cases survived12 cases experienced oliguria,serum creatinine(SCr)increased. Pulmonary function wasrecovered and SCr was gradually returned to normal along with the control of infection. The renal function of other4 cases remained normal. Conclusion CMV pneumonia accompanied ARDS should be treated by antiviral therapy,withdrawal of immuno-suppressant drugs,rebuild the body's immunity function,and timely application ofventilation, which are helpful to improve the successful remedy rate.

2020, 8 (6): 433-435. DOI: 10.3969/j.issn.2095-5332.2020.06.005
Abstract86)      PDF (1799KB)(103)      
Application of magnetic-assisted rapid vascular reconstruction in liver transplantation
Zhang Xiaogang, Liu Xuemin, Zhang Xufeng, Li Yu, Wang Shanpei, Shi Aihua, Lu Qiang, Wang Rongfeng, Wang Bo, Song Jiashu, Lv Yi
2020, 8 (6): 440-445. DOI: 10.3969/j.issn.2095-5332.2020.06.007
Abstract168)      PDF (4119KB)(82)      
Objective To explore the application of magnetic-assisted fast major vascular reconstruction technique in liver transplantation. Methods The clinical data of liver transplant patients undergoing magneticassisted fast major vascular reconstruction and conventional suture reconstruction between November 2018 and December 2019 were retrospectively analyzed. Results A total of five patients were finally enrolled in magneticassisted Liver transplantation(LT), whereas 172 patients underwent regular LT. The donor age, primary disease,as well as the warm and cold ischemia time were comparable between magnetic-assisted and regular LT groups (P > 0.05). In addition, the recipient age, sex, primary disease and preoperative Child-Pugh classification were not different, patients undergoing magnetic-assisted LT experienced an median anhepatic period of 10.3( 9.5~13.2)min, which was significantly shorter versus 43.5( 35.8~ 55.6) min of patients who underwent regular LT (P < 0.001). Of note, postoperative liver transaminase, as well as total bilirubin level were not significantly different at different time stages( P> 0.05). In addition, the incidence of vascular associated complications, such as hepatic artery, portal vein or IVC thrombosis, biliary stenosis, as well as acute renal dysfunction were all comparable between the two groups( P> 0.05). Conclusion Fast revascularization of the donor liver by using the novel magnetics is safe and feasible in LT.
The clinical value of 18F-FDG PET/CT metabolic parameters in the assessment of liver cancer prior to liver transplantation
Ding Enci, Lu Dongyan, Hu Tianpeng, Sun Momo, Feng Xuemin, Shen Jie
2020, 8 (5): 342-348. DOI: 10.3969/j.issn.2095-5332.2020.05.004
Abstract222)      PDF (1113KB)(92)      
Objective To explore the value of 18 F-FDG PET/CT in preoperative evaluation by analyzing the clinical characteristics and PET/CT metabolic parameters of liver transplantation patients with liver cancer. Methods A retrospective study from October 2014 to May 2017 was carried out, a total number of 92 patientswith liver cancer who received liver transplantation and had PET/CT examination pre and post operation in Tianjin First Central Hospital were enrolled. Metabolic parameters were measured or calculated using TrueD software including the maximum standardized uptake value(SUVmax)of normal liver parenchyma,liver cancer lesions and mediastinum,SUV normalized to lean body mass(SUL),tumor metabolic volume(MTV),tumor-to-mediastinum SUV ratio(TMR),tumor-tonormal liver SUV ratio(TLR)and total lesion glycolysis(TLG). The correlation between metabolic parameters and clinical characteristics and their value in predicting pathological indicators were analyzed by one-way analysis of variance(ANOVA), and the correlation between metabolic parameters was analyzed to calculate the Pearson correlation coefficient. Results A total number of 90 patients had a history of hepatitis,including 83 cases of hepatitis B,5 cases of hepatitis C, 1 case of hepatitis B and D,and 1 case of autoimmune hepatitis. The high,medium and low pathological differentiation cases were 28,36 and 22,respectively. Two cases with unclear differentiation and 4 cases had no tumor. There were 90 cases of negative stump or incisal edge of vena cava,portal vein and biliary system,and 2 cases were positive. A total number of 64 cases were negative for satellite nodules and 28 cases were positive. 51 cases were negative of microvascular invasion(MVI)and 41 cases were positive. A total number of 60 patients were negative of detected portal vein and interstitial vascular tumor embolus and 32 cases were positive. The correlation coefficient between the SUVmax of liver background and mediastinum background(LBmax,Mmax)was 0.867,and LBmax was higher than Mmax. The correlation coefficient between SUVmax and SUL was 0.985 and the correlation coefficient between TLR and TMR was 0.986. There was no difference between the metabolic parameters of different TNM stages. There was no significant difference between the metabolic parameters of hepatocellular carcinoma group and cholangiocarcinoma group,no difference was observed in moderately and poorly differentiated groups. There was no difference in the metabolic parameters when considering the tumor number,tumor site,cirrhosis,hepatitis type and activity,cancer thrombus,AFP level,negativity of stump or incisal edge of vena cava,portal vein and biliary,negativity of detected portal vein and interstitial vascular tumor embolus. There were significant differences in SUVmax,TMR,TLR,SUL,MTV and TLG between lymph node metastasis group and non-metastasis group(P < 0.05). There were significant differences in SUVmax,TMR,TLR and SUL and no significant differences in MTV and TLG between satellite nodules negative and positive groups(P < 0.05). There were significant differences in TMR,TLR,SUL and TLG between MVI negative and positive groups(P < 0.05),and there was no significant difference in SUVmax and MTV between the two groups. Conclusion 18 F-FDG PET/CT can evaluate the tumor distribution and stage accurately and comprehensively,identify the degree of tumor differentiation,predict MVI,and so as to predict the prognosis of liver transplantation patients