Objective To understand the status and hot spots of the research on the health management of kidney transplantation recipients in China，to discuss the research deficiencies and development trends，andto provide reference for the development of this field. Methods The relevant literatures were retrieved from CNKI，Wanfang，Weipu and China Biomedical database on August 8，2023，and visualized with CiteSpace and VOSviewer. Results A total of 678 Chinese literatures were retrieved，the number of which showed anincreasing trend. The published journals were concentrated，and the cooperation between authors and institutions was limited and regional. Research hotspots included medication compliance，self-management，quality of life，social support，the frontier areas include telemedicine，life-cycle follow-up management，and evidence-based nursing. Conclusion The study on the health management of kidney transplant recipients has gradually changed from passive health education to active health promotion，but the research force still needs to be strengthened. It is recommended to apply telemedicine and evidence-based concepts，improve the follow-up management system，andstrengthen the follow-up management of the whole life cycle. 

 Objective To elucidate the relationship between preoperative immunotherapy，the abundance of tertiary lymphoid structures（TLS）in hepatocellular carcinoma（HCC）tissues，and to evaluate patient prognosis following liver transplantation. Methods The clinical data of 149 liver transplant patients with liver cancer at Huashan Hospital Affiliated to Fudan University from January 2018 to December 2023 were retrospectively analyzed. Pathological slides of each patient were scored for TLS. Patients were categorized into four groups based on downstaging treatment outcomes ：those initially meeting the Milan criteria（n ＝ 35），those exceeding the Milan criteria without downstaging treatment（n ＝ 38），successful downstaging cases（n ＝ 33），and unsuccessful downstaging cases （n ＝ 43）. Kaplan-Meier analysis and the log-rank test were employed for survival analysis. The correlation betweenimmunotherapy and TLS abundance was assessed using non-parametric statistical methods. Results Survival analysis of the overall cohort revealed that patients with high intratumoral TLS abundance had significantly higher recurrence-free survival（RFS）than those with low TLS abundance（P ＜ 0.05）. Among patients receiving downstaging treatment，the recurrence risk in the successful downstaging group was significantly lower than in the unsuccessful group（P ＜ 0.05）. Non-parametric testing of the successful downstaging group demonstrated that preoperative immunotherapy significantly increased intratumoral TLS abundance（P ＜ 0.05）. Similarly，nonparametric testing of all patients receiving immunotherapy showed a statistically significant increase in intratumoral TLS abundance in the successful downstaging group（P ＜ 0.05）. Conclusion Successful downstaging withpreoperative immunotherapy improves the prognosis of HCC patients undergoing liver transplantation，potentially by enhancing intratumoral TLS abundance. 

ObjectiveThis survey was conducted to get some knowledge about the growth status and intestinal microecology of pediatric liver transplantation patients. MethodsA total of 30 children’s stool sample were collected, the samples were analyzed by gene sequencing. Meanwhile, the clinical data and personal information were included into analysis. ResultsThe average month age was （6.1±1.5）m. The average height, weight and body mass index （BMI） were （65.8±3.7）cm, （6.7±1.1）kg and 15.1±1.6, respectively. As for the gender, 10 cases were men while 20 cases were women. The most common blood type was A which accounted for 33.3%, followed by B（23.3%）, O（30.0%） and AB（13.4%）. There were statistical differences between normal and abnormal groups in weight, BMI, weight Z score and BMI Z score on the operation day. However, 18 months after operation, there were statistical differences betweentwo groups in height and weight. ConclusionLiver transplantation can improve the growth of biliary atresia patients, and intestinal flora correlates to growth. 

Objective To establish a digital health management system for the full life cycle of organ transplant recipients （SWOR） and to summarize the trial experience with SWOR. Methods SWOR was built using a smartphone app and a WeChat mini-program. It consists of modules for medical procedures，daily health metrics，test results，imaging reports，medication plans，and doctor-patient communication. Recipients input relevant information through the patient interface，while the follow-up team uses the physician interface to randomly select recipients and review their data，including time-series data curves generated from these modules. Results Between March 2019 and May 2024，1 730 organ transplant recipients participated in the trial， comprising 1 235 males and 477 females，with 1 648 adult and 82 pediatric recipients. The trial included recipients of all organ transplant types ：liver（57.5%），kidney（28.2%），lung（6.13%），heart（2.83%），pancreas（0.17%），small intestine（0.06%），and combined transplants（5.14%）. Randomly extracted data from the SWOR system showedthat the module contents and follow-up indicators were effectively displayed，and the data was clearly represented intime-series curves. Conclusion This study provides preliminary evidence that SWOR offers a practical digital tool for managing the health of organ transplant recipients. 

Objective To summarize the experience in the treatment of antibody mediated rejection（AMR）after kidney transplantation. Methods A retrospective analysis was conducted on kidney transplant recipients who was diagnosed as AMR by biopsy in the Third Medical Center of the General Hospital of the People's Liberation Army from 2018 to 2021. Regular follow-up and prognosis were analyzed after treatment. The survival time of the graft between different time of rejection after transplantation，pathological type，DSA type，and number of kidney transplants were compared，and factors that may affect prognosis were preliminarily screened. Results The results showed that 14 recipients were diagnosed with AMR. After combination therapy of plasma exchange，lymphocyte depleting antibody and immunoglobulin treatment，the overall 1-year graft survival rate was 78.6%，and the 5-year survival rate was 43%. Within 6 months after treatment，3 cases with infection required hospitalization，including 1 case of cutaneous herpes zoster infection，1 case of urinary tract infection，and 1 case of diarrhea. There were nolife-threatening or graft loss case directly related to infection. Conclusion A combination treatment based on plasma exchange can achieve some effects in the treatment of antibody mediated rejection after kidney transplantation. Further research is needed on the optimization of protocols for different types of rejection. 

Objective To investigate the care burden of family caregivers of liver transplant recipients andto explore its influencing factors. Methods Convenience sampling method was used to select the family caregivers of liver transplant recipients who visited the Organ Transplantation Center of Qingdao University Affiliated Hospital from June 2022 to December 2022 as the research subjects. A total of 205 family caregivers of adult liver transplant recipients wereselected by convenience sampling method and investigated with the General Information Questionnaire ： Zarit CaregiverBurden Interview（ZBI）. Results The score of caregiver burden of liver transplant recipients was （28.84±14.33）， and67.8% of them had moderate and severe level of caregiver burden. Univariate analysis showed that there were statisticallysignificant differences in the level of care burden between liver transplant recipients with postoperative complications and their self-care ability， family caregivers with other diseases， family monthly income， daily care time and total caring time （P ＜ 0.05）. Multiple linear regression results showed that the self-care ability of liver transplant recipients and whetherfamily caregivers had other diseases were the influencing factors of care burden （P ＜ 0.05）. Conclusion The familycaregivers of liver transplant recipients have a certain degree of care burden. While providing nursing care for recipients，medical staff should also pay attention to their family caregivers and take timely targeted interventions to reduce the careburden and improve the overall quality of life.