关键词:

 , 血型不合 , 儿童 , 肝移植 , 排斥反应 , 存活率

Abstract:

Objective To investigate the clinical outcomes and prognosis of ABO incompatible livertransplantation in children. Methods A retrospective analysis of clinical data from 1607 pediatric liver transplant recipients at the Pediatric Organ Transplantation Department of Tianjin First Central Hospital between January 1， 2014， and December 31，2022 was performed. Recipients were categorized into three groups based on ABO blood typecompatibility with donors ： Group A （ABO-identical，1077 cases）， Group B （ABO-compatible，288 cases）， and Group C（ABO-incompatible，242 cases）. Postoperative complications， patient survival rates， and graft survival rates were observed and compared among the three groups. Results The overall 1，3， and 5 year survival rates of the 1，607 recipients were 95.7%，94.6%， and 94.0%， respectively， with no significant differences （P ＝ 0.797）. Similarly， there were no significant differences in graft survival rates at 1，3， and 5 years among the three groups （P＝ 0.366）. However， there were significant differences in the incidence of postoperative complications， including cellular rejection （P ＜ 0.001）， biliary stricture （P ＝0.016）， and hepatic artery thrombosis （P ＝ 0.030）， among the three groups. Conclusion Pediatric ABO incompatibleliver transplantation is safe and feasible， effectively expanding the donor pool and benefiting more pediatric patients. 

Key words:

ABO incompatibility,  , Children,  , Liver transplantation,  , Rejection,  , Survival rate