关键词:

ABO 血型不相容 , 儿童 , 活体肝移植

Abstract:

Objective The objective of this study is to examine the clinical efficacy and prognosis of ABO incompatible live donor liver transplantation in children， thereby offering valuable insights for clinical practice in this particular area. Methods The data of 22 children who underwent living donor liver transplantation in the Department of Pediatric Surgery， the First Affiliated Hospital of Xinjiang Medical University from 2021 to 2023 were retrospectively analyzed. There were 16 cases in the ABO-identical （ABO Id） or ABO-compatible （ABO-C） group. There were 6 cases inthe ABO-incompatible （ABO-In） group. The general data， postoperative indicators，complications and survival of the twogroups were compared. Results There was no statistically significant difference between the two groups in transplant age， gender， operation history， PELD score， donor age， anhepatic phase， operation time， postoperative hospitalization duration， tacrolimus whole blood trough concentration， and serum creatinine value （P ＞ 0.05）. There was no significant difference in the overall cumulative survival rate between the two groups （P ＞ 0.05）. There was no significant difference in the incidence of postoperative pulmonary infection，cytomegalovirus infection， rejection and vascular complications between the two groups （P ＞ 0.05）. Conclusion ABO incompatible living donor liver transplantation in children is a safe andeffective treatment， which can increase the source of donor liver and save the lives of children. 

Key words:

ABO blood type incompatible,  , Pediatric,  , Living donor liver transplantation