实用器官移植电子杂志

实用器官移植电子杂志 ›› 2021, Vol. 9 ›› Issue (4): 294-298.DOI: 10.3969/j.issn.2095-5332.2021.04.008

• 论著 • 上一篇    下一篇

肝移植治疗儿童胆道闭锁合并肝脏恶性肿瘤 4 例报告

徐敏，孙超，覃虹，韩潮， 张复波，杨洋，高伟   

  1. 天津市第一中心医院儿童器官移植科，天津 300192

  • 出版日期:2021-07-20 发布日期:2023-04-12

Liver transplantation for biliary atresia with hepatic malignant tumor：report of 4 cases

Xu Min，Sun Chao，Qin Hong，Han Chao，Zhang Fubo，Yang Yang，Gao Wei.
  

  1. The Department of Children's OrganTransplantation，Tianjin First Central Hospital ，Tianjin 300192，China.
  • Online:2021-07-20 Published:2023-04-12

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摘要：

目的 探讨肝移植治疗儿童胆道闭锁（biliary atresia，BA）合并肝脏恶性肿瘤的临床疗效及预后。方法 2015 年 1 月 1 日— 2019 年 12 月 31 日期间天津市第一中心医院儿童器官移植科的儿童肝移植患者中，有 4 例原发疾病为胆道闭锁合并肝恶性肿瘤，回顾性分析这 4 例患者的临床资料。结果 4 例患者中 BA 合并肝母细胞瘤（hepatoblastoma，HB）3 例，BA 合并肝细胞癌（hepatocellular carcinoma，HCC）1 例，所纳入的患者术前均诊断 BA，其中 1 例术前诊断为 BA 合并 HB，其余 3 例为肝移植术后病理诊断为BA 合并 HB 或 HCC。4 例患者肝移植术后均顺利恢复，术后中位随访时间为 25.5 个月，4 例患者全部存活，随访期内均未发现肿瘤复发。结论 肝移植是 BA 合并肝脏恶性肿瘤的有效治疗方式，对于低风险患者，移植术后未行辅助化疗的近期疗效确切，远期疗效尚需进一步研究。

关键词:

儿童 , 胆道闭锁 , 肝脏恶性肿瘤 , 肝移植

Abstract:

Objective To investigate the clinical efficacy and prognosis of liver transplantation in children with biliary atresia combined with liver cancer. Methods From January 1，2015 to December 31，2019，there were 4 cases of biliary atresia combined with liver cancer in the Tianjin First Central Hospital. The clinical data of these 4 cases were analyzed retrospectively. Results Among the 4 biliary atresia patients，there were 3 cases complicated with hepatoblastoma and 1 case complicated with hepatocellular carcinoma. All the patients were diagnosed with biliary atresia preoperatively，1 case was diagnosed with hepatoblastoma preoperatively，and the other 3 cases were diagnosed with hepatoblastoma or hepatocellular carcinoma postoperatively. The median follow-up time was 25.5 months. All the 4 patients survived and no recurrence was found during the follow-up period. Conclusion Liver transplantation is an effective treatment for biliary atresia combined with liver cancer. For low-risk patients，the short-term effect without adjuvant chemotherapy after transplantation is definite，and the long-term outcomes need to be studied further.

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