Objective To investigate the donor risk factors for post-liver transplantation infection in donation after the death of citizens. Methods A retrospective analysis of the clinical data of 100 patients from January 1，2015 to December 31，2019 at Zhongshan People's Hospital was performed. The patients accepted organ donation after the death of citizens for liver transplantation. The patients were divided into infection group and non-infection group according to the postoperative infection status of the patients. Univariate analysis was performed on possible factors related to donor-associated infection after liver transplantation，and related factors were included in multivariate logistic regression. Predictive or risk assessment of infection after liver transplantation were analyzed. Results The univariate analysis revealed that the donor albumin ratio，donor total bile acid and donor albumin score were related to infection after liver transplantation（P ＜ 0.05）. Multivariate logistic regression analysis showed that donor total bile acid and donor albumin scores were independent related factors for infection after liver transplantation（P ＜ 0.05）. Conclusion Low donor total bile acid and donor albumin scores before surgery were associated with lower risk of infection after liver transplantation.