Objective To investigate the effect of donor-derived infections on the recipients with liver transplantation（LT）. Methods We conducted a retrospective analysis on the clinical data among 47 donation after cardiac death（DCD）donors from January 2017 to November 2017 in Beijing Friendship Hospital， Capital Medical University. The patients were divided into positive and negative groups according to the culture result of perfusion fluid. Then these culture results of perfusion fluids were analyzed with the culture results of sputum and drainage fluid after LT，in order to show the correlation between patient infection and donor-derived pathogen. Results In 47 patients，sixteen were in positive group，and thirty-one patients in negative group. Nineteen patients suffered from infections after LT，including nine patients with positive results in sputum culture， and twelve patients with positive results in drainage fluid culture. In positive group，sputum cultures of six patients were positive，and results of drainage fluid culture were positive in eight patients. In six patients，pathogens were same in drainage fluids and perfusion fluids. In negative group，three patients were positive insputum culture，four patients were positive in drainage fluid culture. Finally，there was one patient died of multiple organ failure in positivegroup. Other recipients in positive group survived well after anti-infective treatments. The recipients in negative group were all survived well. Conclusion Donor-derived infections had an effect on the infection and prognosis of recipients after LT