Abstract:

Objective The aim of this study was to investigate the risk factors，clinical features and prophylaxis of de novo cancers after liver transplantation. Methods Clinical data of 8 patients with the digestivesystem malignant tumor out of 1 809 patients who underwent liver transplantation and these patients who received complete follow-up in the First Central Hospital of Tianjin from January 2006 to January 2013 were analyzedretrospectively. Smoking and alcohol history，protopathy，blood concentration，prophylaxis of de novo cancers，diagnosis process and prognosis were summarized. Results The incidence of malignancies in digestive system after liver transplantation in our hospital was 0.44%（8/1 809），including 3 cases of colon cancer，2 cases of gastric cancer，2 cases of liver cancer，1 cases of esophageal cancer. The dosage of FK506 was reduced when patientsreceived the corresponding treatment when they had been diagnosed as malignancies. Up to the date of submission，8 patients were followed up for 3-62 months，the median time was 18.5 months and the fatality rate was 50%，bothdied of tumor progression and multiple organ failure. Conclusion Immunosuppression，primary disease，drinking and smoking history，age and virus infection may be high risk factors of malignancy following liver transplantation. The reduction of immunosuppression to the lowest level compatible with good allograft function and prophylactic measuresagainst certain viral infections is the most important preventive measure.