Abstract:

Objective To analyse radiofrequency ablation in combination with local injection of anhydrousalcohol effects on the quality of life and prognosis in primary liver cancer. Methods Radiofrequency ablation in combination with anhydrous alcohol local injection treatment of 204 patients from January 2011 to December 2014in Inner Mongolia medical University affiliated hospital with primary liver cancer were analyzed，random number table method was used to divide them into control group（104 cases）and the treatment group（100 cases）. Patientsin control group underwent ultrasound guided percutaneous absolute alcohol injection，treatment group was given radiofrequency ablation combined therapy with local injection of anhydrous alcohol，observation period lasted for3 months. The changes of liver function and AFP before and after the treatment of these two groups were measured. The European organization for research and treatment of cancer quality of life scale（EORTC QLQ C30）was usedto evaluate the quality of the patients life changes. To observe the recurrence rate and survival period，using theLogistic regression analysis of risk factors was performed for prognosis. Results Before the treatment，alanineaminotransferase（ALT），aspartate transaminase（AST），total bilirubin，albumin and alpha fetoprotein（AFP）levelin the control group and treatment group had no statistically significant difference（P ＞ 0.05）；After treatment，compared with control group patients，ALT，AST，total bilirubin，albumin and AFP level in treatment group wassignificantly lower〔ALT（U/L）：30.16±18.55 vs. 39.56±20.48，AST（U/L）：32.25±19.48 vs. 40.44±21.56，total bilirubin（μmol/L）：5.40±2.57 vs. 9.54±3.25，albumin（g/L）：42.54±6.89 vs. 40.24±6.87，AFP（μg/L）：154±82 vs. 223±107，all P ＜ 0.05〕. Before treatment，there were no statistically significant difference in control group and treatment group patients’quality of life ；After treatment，the treatment grouppatients’general health，physical function，social function score were higher than the control group. Compared with control group，nausea and vomiting，pain，fatigue，insomnia，diarrhea，loss of appetite score decreased，the difference had statistical significance〔general function（score）：71.63±10.65 vs. 65.24±11.21，physical function（score）：89.04±8.60 vs. 85.26±8.53，social function（score）：72.88±13.22 vs. 65.59±13.06，nausea and vomiting（score）：16.33±14.33vs. 27.36±19.22，pain（score）：17.28±11.77 vs. 25.32±10.07，fatigue（score）：17.67±11.20 vs. 28.87±12.05，insomnia（score）：14.38±14.57 vs. 28.50±20.36，diarrhea（score）：4.98±8.24 vs. 15.98±20.05，loss of appetite （score）：13.55±15.25 vs. 29.77±20.21，all P ＜ 0.05〕. A total number of 190 patients were followed up and，thefollow-up rate was 93.14%，there were 108 surviving patients，82 patients died. Multivariable Logistic regression analysis showed that the disease position，ALT，AFP level before treatment，intraoperative blood transfusion，operation method，tumor recurrence and radiofrequency ablation combined local injection of anhydrous alcohol associated with prognosis after treatment of primary liver cancer（P ＜ 0.05）. Conclusion Radiofrequency ablation in combination with local injection of anhydrous alcohol is a kind of effective method of treatment in primary liver cancer. The prognosis of primary liver cancer was associated with the position and ALT，AFP level beforetreatment，intraoperative blood transfusion，operation method and tumor recurrence.