实用器官移植电子杂志

实用器官移植电子杂志 ›› 2019, Vol. 7 ›› Issue (2): 113-116.DOI: 10.3969/j.issn.2095-5332.2019.02.006

• 论著 • 上一篇    下一篇

肾移植围术期红细胞免疫功能变化探讨

周结学，刘东，吴家清，蒙善东，申升，朱春丽，邓庚国，马娟，郑克立   

  1. 广东省第二 人民医院器官移植科，广东 广州 510317
  • 出版日期:2019-03-20 发布日期:2021-06-23
  • 基金资助:
    广东省医学科技研究基金项目（B2016104）

Investigation on changes of erythrocyte immune function in perioperative period of renal transplantation

Zhou Jiexue，Liu Dong，Wu Jiaqing，Meng Shandong，Shen Sheng，Zhu Chunli，Deng Gengguo，Ma Juan， Zheng Keli.   

  1. Department of Organ Transplantation，Second People's Hospital of Guangdong Province， Guangzhou 510317，Guangdong，China.
  • Online:2019-03-20 Published:2021-06-23

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摘要：

目的 探讨肾移植受者围术期血红细胞免疫功能及 CD4、CD8 淋巴细胞的变化。方法 选取 2013 年 1 月—2017 年 3 月肾移植受者 25 例，25 例健康体检者作为对照组，分别于术后 3 d、7 d、14 d、1 个月、3 个月采集外周血行红细胞免疫功能和 CD4、CD8 淋巴细胞数检测，观察红细胞免疫功能和淋巴细胞数的变化情况。结果 肾移植受者术前红细胞花环率低于对照组，其表面膜分子 CD35、CD58、CD59 表达也低 于对照组，而 CD4、CD8 淋巴细胞数稍低于对照组，术后红细胞花环率、CD4、CD8 淋巴细胞数呈现先下降后逐步恢复的过程，其表面膜分子 CD35 于术后呈现先降后升现象，CD58、CD59 于术后呈现先轻微上升，后逐步恢复。结论 肾移植受者术前红细胞免疫功能低于对照组 , 术后有所改善，其变化与淋巴细胞变化基本一致，红细胞免疫可能参与到淋巴细胞及肾移植受者机体免疫功能的调节。

关键词: 肾移植 , 红细胞 , 免疫

Abstract:

Objective To observe the changes of erythrocyte immune function and CD4，CD8 lymphocytenumber during perioperative period in renal transplant recipients. Methods A total of 25 recipients withkidney transplantation during January 2013 and March 2017 were chosen as the observation group，and 25 healthycontrols taking physical examinations were chosen as the control group. The erythrocyte immune function and the number of CD4，CD8 lymphocytes before and on the 3 d，7 d，14 d，1 month and 3 months after the transplantation was detected so as to observe the changes of immune function of red blood cells and the number of CD4，CD8 lymphocytes. Results The red cell rosette in the observation group were lower than those in the control group，the CD35，CD58，CD59 expressions before the transplantation in the observation group were lower than those in thecontrol group. The number of CD4，CD8 lymphocytes were slightly lower than the control group. Red cell rosette and the number of CD4 and CD8 lymphocytes decreased at first，and then gradually recovered. The surface CD35 dropped at first after the operation，and the CD58 and CD59 showed a slight increase after the operation，and then gradually recovered. Conclusion The immune function of erythrocyte was weak in recipients before transplantation，but the function can be recovered after transplantation. Its changes were basically consistent with lymphocytechanges，the erythrocytes immunity was involved in the regulation of immune function of lymphocytes and renaltransplant recipients.

Key words: Renal transplantation, Red blood cells, The immune

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