Objective To investigate whether pre-procurement donor hypernatremia affects early graft recovery after liver transplantation. Methods A retrospective study was conducted by collecting the clinical data of 118 patients undergoing liver transplantation at the First Affiliated Hospital of Zhengzhou University from January 2016 to December 2018. According to the preoperative primary disease，the recipients were divided into hepatocellular carcinoma group and non-hepatocellular carcinoma group. The recipients were divided into normal blood sodium concentration group（＜ 160 mmol/L）and hypernatremia group（＞ 160 mmol/L）according to the preoperativeblood sodium concentration in donors. The difference in model for end stage liver disease（MELD）score，aspartatetransaminase（AST），alanine aminotransferase（ALT），total bilirubin（TB）and other postoperative AST，ALT，TB and postoperative intensive care unit（ICU）and hospitalization time were analyzed. The effects of donor hypernatremia on early recovery of recipients after liver transplantation were analyzed. Results There was no statistical difference between the liver cancer group and the non-hepatocellular carcinoma group before and during the operation. There were no significant differences in liver function at 1 st，3 rd，5 th，30 th and 90 th postoperatively days in two groups. The liver function recovery at the 30 th and 90 th postoperative days，postoperative ICU stay and total hospital stayshowed no significant differences in two groups. Conclusion Donor hypernatremia before donor procurement hadno significant effect on early recipient recovery after liver transplantation。

Objective To analyze the incidence rate，treatment and the clinical effect of renal artery stenosisin patients with renal allograft dysfunction. Methods The clinical data of 52 patients with renal allograft dysfunctionin our hospital from November 2018 to March 2019 were reviewed retrospectively. The study mainly includedrotational intra-arterial digital subtraction angiography（DSA），interventional treatment of renal artery stenosis and the clinical effects. Results A total number of 24 of 52 cases（46.1%）encountered obvious renal artery stenosis and the degrees of stenosis were from 28% ～ 95% with an average of 66.96%. The stenosis included：① Anastomotic stenosis ；② Flex of renal artery ；③ Segmental stenosis of renal artery ；④ Thrombosis of Internal iliac artery. 21 of 24 cases received interventional therapy，1 case was received the resection of the transplanted kidney because of thrombosis，2 cases refused any therapy. 17 of 21 cases（73.9%）showed a stable decrease in serum creatinine valuewithin 1 to 3 weeks，and the mean blood creatinine value decreased from 269.6 μmol/L before interventional therapy to 190.1 μmol/L，with a decrease of 29.5%. Conclusion Arterial stenosis is a common complication in recipientswith renal allograft dysfunction and should be emphasized and screened routinely. Interventional therapy is thepreferred treatment method for arterial stenosis，early detection and treatment could achieve certain clinical effects. 

Objective To investigate the risk factors of early stage renal replacement therapy for acute kidney injury after heart transplantation and its effect on short-term prognosis. Methods We retrospectively studied 77 consecutive heart transplant recipients from January 2013 to June 2019，15 patients of them accepted renal replacement treatment for acute kidney injury at early stage（RT group），and the other 62 patients didn`t（NRT group）. The age，BMI，protopathy，renal function before operation，operation model，duration of cardiopulmonary bypass，aortic crossclamp time，volume of blood transfusion and fresh frozen plasma transfusion were comparedbetween the two groups，and the 28 d mortality were analyzed. Results The patients of RT group were older thanthat of NRT group〔（58.70±7.70）years vs（52.80±12.70）years，P ＝ 0.028〕. The estimated glomerular filtration rate（eGFR）before operation were much lower in RT group〔（61.00±22.86）ml/min vs（75.34±25.16）ml/min，P ＝ 0.048〕. And more fresh frozen plasma were transfused to patients of RT group〔（1423.33±572.44）ml vs（1053.71±560.77）ml，P ＝ 0.024〕. Besides，most patients accepted heart transplantation，two patients in RT group accepted intra-aortic balloon pulsation simultaneously and 1 patients in NRT group accepted combinedcardiopulmonary transplantation. Patients with renal replacement therapy had a greater 28 d mortality（53.33% vs 8.06%，P ＜ 0.001）. Conclusion The early stage renal replacement therapy after heart transplantation is a frequent complication associated with a high short-term mortality and is mainly associated with older age，preoperative renal function impairment and more fresh frozen plasma transfusion during operation.

Objective To investigate the relationship between the expression of human heterogeneous nuclear Ribonucleoproteins A1（HNRNPA1）and recurrence，metastasis and prognosis in patients with small hepatocellular carcinoma（HCC）after salvage liver transplantation. Methods The relationship between HNRNPA1 and clinicopathological features，recurrence，metastasis and prognosis were analyzed by qRT-PCR and immunoh istochemistry. Results The expression of HNRNPA1 was significantly higher in HCC tissues（P ＜ 0.01），and correlated with patients with hepatocellular carcinoma（P ＜ 0.05）. The expression of HNRNPA1 was correlatedwith tumor envelope，vascular invasion and recurrence（P ＜ 0.05）. COX regression analysis showed that the high expression of HNRNPA1 was an independent risk factors for the prognosis of early HCC salvage liver transplantation.Conclusion HNRNPA1 may be involved in the occurrence and development of HCC and may be associated withpoor prognosis in patients undergoing remedial liver transplantation.