Objective To observe the histological characteristics of margin donor livers and evaluate the histological criteria of donor liver for transplantation. Methods A total number of 17 cases of margin donor liver were collected. The histological patterns was analyzed by frozen section examinations and routine hematoxylin-eosin（HE）staining. Results The main histological characteristics were ：① steatosis of hepatocytes ；② liver fibrosis ；③ necrosis of hepatocytes ；④ cholestasis of hepatocytes and capillary bile duct. Conclusion Hepatic steatosis，fibrosis and necrosis could be used as morphological basis for preoperative evaluation.

Objective To discuss the clinical and pathological features of the rare cases with idiopathicnoncirrhotic portal hypertension（INCPH）who required orthotopic liver transplantation（OLT），along with thepostoperative complications. Methods Combined with the clinical and pathological data，the diagnosis and treatment of 2 cases with INCPH who underwent OLT at Zhongshan Hospital from December 2016 to June 2019 were analyzed retrospectively. To evaluate the curative effect of OLT，close laboratory examination and radiological follow-up were performed post-transplantation，liver biopsy was performed when necessary. Results The diagnosis of INCPH were histologically confirmed，and the surgeries went smoothly. After OLT，chronic rejection was found in onecase，and the disease recurred 1 year after the liver retransplantation. Cytomegalovirus infection，inferior vena cavalthrombosis and biliary tract complications were found in the other case. Conclusion INCPH can be a rare cause of end-stage liver disease requiring liver transplantation which is misdiagnosed frequently. Considering the limited relevant experiences to be referred to and the concerns about complications and recurrence. The efficacy of OLT forINCPH remains to be evaluated.

Objective To analyze the clinical characteristics and treatment of graft-versus-host disease（GVHD）after renal transplantation，and to explore the diagnosis and treatment of GVHD after renal transplantation. Methods A rare case of GVHD after renal transplantation in our hospital was retrospectively analyzed. The patient was admitted to hospital 25 days after kidney transplantation because of skin damage，fever，hematemesis and blackstool. He was highly suspicious of GVHD. In orderto make a definite diagnosis，skin biopsy was performed at the lesion. Immunosuppressive agents were discontinued and low dose methylprednisolone was given. Immunoglobulin combined with thymosin enhanced immunity and anti-infection. Nutritional support，colony stimulating factor，plasma transfusion，platelet transfusion，skin care and continuous bedside ultrafiltration were given for leukopenia and thrombocytopenia.Results Pathological report of skin biopsy showed that the basal layer cells of skin epidermis had vacuolardegeneration，eosinophilic necrosis in epidermis，infiltrative GVHD changes of lymphocyte in dermis，combined with the clinical symptoms of patients，GVHD after kidney transplantation was diagnosed. After the above treatment，the patient's condition once improved，and the treatment program played a certain role. But the patient eventually died of hemorrhagic shock and multiple organ failure. Conclusion GVHD is extremely rare in kidney transplantation patients，its clinical manifestations are atypical，which leads to delayed diagnosis，rapid progression of GVHDand poor prognosis. In clinical work，when the patients have fever，rash，diarrhea and bone marrow depression ofunknown causes after transplantation，GVHD should be highly suspected. Skin biopsy is a feasible method to diagnoseGVHD. At the same time，low dose methylprednisolone bolus therapy should be given. Immunoglobulin combined with thymosin can enhance immunity. Drug therapy such as Li may benefit more.