Abstract:

Objective To investigate the relationship between the expression of human heterogeneous nuclear Ribonucleoproteins A1（HNRNPA1）and recurrence，metastasis and prognosis in patients with small hepatocellular carcinoma（HCC）after salvage liver transplantation. Methods The relationship between HNRNPA1 and clinicopathological features，recurrence，metastasis and prognosis were analyzed by qRT-PCR and immunoh istochemistry. Results The expression of HNRNPA1 was significantly higher in HCC tissues（P ＜ 0.01），and correlated with patients with hepatocellular carcinoma（P ＜ 0.05）. The expression of HNRNPA1 was correlatedwith tumor envelope，vascular invasion and recurrence（P ＜ 0.05）. COX regression analysis showed that the high expression of HNRNPA1 was an independent risk factors for the prognosis of early HCC salvage liver transplantation.Conclusion HNRNPA1 may be involved in the occurrence and development of HCC and may be associated withpoor prognosis in patients undergoing remedial liver transplantation.

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摘要：

目的 探讨人异质性胞核核糖蛋白 A1（heterogeneous-nuclear ribonucleo proteins A1，HNRNPA1）表达与小肝癌（hepatocellular carcinoma，HCC）补救性肝移植患者临床预后的关系。方法 运用 qRT-PCR 法、免疫组织化学法等方法分析 HNRNPA1 与临床病理特征及预后的关系。结果 HNRNPA1 高表达与肝癌患者的预后相关（P ＜ 0.05），与肿瘤包膜、血管侵犯、肿瘤复发相关（P ＜ 0.05）；COX 回归分析显示HNRNPA1 高表达、血管侵犯、肿瘤包膜是早期 HCC 补救性肝移植预后的独立危险因素。结论 HNRNPA1可能参与 HCC 的发生发展过程，并与补救性肝移植患者不良预后相关。

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