2018, (1):
34-38.
Objective To study the surgical technique and clinical effect of combined transplantation of
abdominal organ cluster（liver，pancreas-duodenum）and kidney for the treatment of posthepatitic cirrhosis combined
with uremia and insulin-dependent diabetes mellitus. Methods A patient suffered from Hepatitis B cirrhosis,
uremia and insulin-dependent diabetes mellitus underwent abdominal organ cluster and kidney transplantation in
July, 2016. After the patient’s liver was removed, the organ cluster involving liver, pancreas and duodenum was
implanted orthotopically. The hepatic vein of liver was anatomosed in classic pattern. The recipient's portal vein was
then anastomosed to the side of the donor portal vein above the upper border of donor pancrea. The common hepatic
artery and superior mesenteric artery of graft were reconstructedwith branches of an iliac artery and their common
trunck was anastomosed to the recipientt's common hepatic artery. The side wall of graft duodenum was anastomosed
to of the side wall of native proximal jejunum in manner of Roux-en-Y. The kidney graft was placed in right iliac
fossa. Abdominal organ cluster and kidney were from a same donor. A quadruple immunosuppressive regimen
including anti-IL-2 receptor antibody（simulect）, tacrolimus, mycophenolate mofetil（MMF）and steroids was
employed to prevent rejection. Results Two weeks after the operation, the liver and kidney functions returned to
their normal ranges. Insulin was weaned off 3 weeks after operation, and the blood glucose level remained normal afterthat. Conclusion Combined abdominal organ cluster and kidney transplantation was an effective method to treat
end-stage liver disease, uremia and type 2 diabetes mellitus.
