Abstract:

Objective To clear the pathological characteristics of various complications following liver transplantation in a series of samples. Methods The clinical data of 34 patients were collected，who underwent allogeneic liver transplantation between July 2011 to August 2017 in Liver transplantation center，The First Affiliated Hospital of Zhengzhou University. The biopsy tissues were stained by HE method． Masson trichrom staining and immunohistochemical staining were performed in part of samples．Histological patterns were observed，and complications were determined. Results A total number of 33 liver-transplant patients were studied，including 28 male and 5 female. The average age was 42.3±12.9. One patient underwent the liver biopsy for two times. The diagnoses were as following ：HBV-related hepatocirrhosis in 13 cases，HCV-related hepatocirrhosis in 2 cases， alcoholic liver cirrhosis in 4 cases，cryptogenic cirrhosis in 1 case，hepatitis B with hepatocellular carcinoma in 8 cases，hepatolenticular degeneration in 2 cases，primary biliary cirrhosis in 1 case，biliary atresia in 1 case and congenital hepatic fibrosis in 1 case. Among of them，ischemia-reperfusion injury（2 episodes，5.9%），Acute cellular rejection（15 episodes，44.1%），biliary tract complication（4 episodes，11.8%），drug toxicity（12 episodes，35.3%） and primary graft non-function（1 episodes，2.9%）were found. Conclusion Liver biopsy plays an important role in the diagnosis of the complications following liver transplantation.