Objective To investigate the treatment of donor derived carbapene-resistant Klebsiella pneumoniae（CRKP）infection after liver and kidney transplantation. Methods The clinical data including treatment processes of the liver transplantation and renal transplantation recipients who infected by carbopenemresistant Klebsiella pneumonia in the Department of Orthopaedics，Renji Hospital，the Affiliated Hospital of Shanghai Jiao Tong University in 2017 were analyzed retrospectively. Results In 2017，a donor derived infection with CRKP was diagnosed definitely in one liver recipient. Though septic shock arisen，the infection was controlled by a combination therapy of antibiotics（ Meropenem + Tigecycline + Fosfomycin）for 3 weeks. There was a pair of renal transplant recipients with grafts from the same donor. 1 case showed infection around the transplanted kidney 10 days after surgery. Although the kidney was removed，the patient died eventually. The other patient who had the similar infection around the transplanted kidney 22 days after surgery，was treated with carbapenase inhibitor combined with carbapenem. This patient recovered quickly. Conclusion In terms of postoperative donor derived CRKP infection，the main presentation was septicopyemia in liver transplant recipients，and was relatively easy to control.Renal transplantation recipients has a relative later onset，which was presented as a local infection of transplanted kidney，and more difficult to control. Additionally a combination of carbapenase inhibitor with carbapenem should be considered.