人工肝 , 肝衰竭 , 肝性脑病 , 总胆红素存留率 , 总胆红素反弹率 , ΔMELD 评分

Objective To evaluate the prognosis of patients combined with acute（subacute）hepatic failure and hepatic encephalopathy after artificial liver treatment. Methods The clinical data of 25 patients who received artificial liver treatment were collected. Parameters including total bilirubin，albumin，prothrombin activity and blood ammonia before and after treatment were collected. Total bilirubin clearance rate（TBCR），total bilirubin actual resident ratio（TBARR），total bilirubin rebound rate（TBRR）and ΔMELD score were compared. Results The Prothrombin activity and ammonia clearance were higher in the improvement group，the TBARR，TBRR and ΔMELD score were lower in the improvement group compared with deterioration group，the differences were statistically significant（P ＜ 0.05）. There was no difference between the two groups in albumin ，blood ammonia and MELD score. The AUC of TBARR、 TBRR and ΔMELD was 0.794、0.816、0.897. Conclusion TBARR，TBRR and ΔMELD could predict the prognosis of patients with artificial liver treatment ，of which Δ MELD could predict the prognosis more precisely.