关键词:

肺动脉高压 , 肺移植 , 心功能 , 体外膜肺氧合

Abstract:

Objective To retrospectively summarize the perioperative clinical data of patients with endstage pulmonary arterial hypertension undergoing lung transplantation， and to analyze the recovery of cardiac function after surgery. Methods A retrospective analysis was conducted on six patients with end-stage pulmonary arterial hypertension who underwent lung transplantation at the Department of Lung Transplantation of ChinaJapan Friendship Hospital from March 2017 to June 2024. The general information of the patients before surgery， preoperative cardiac function， perioperative use of ECMO and IABP， and the recovery of cardiac function after surgery were analyzed. Results Among the six patients， three were male， and the median age was 33.5 years old. Four patients were diagnosed with idiopathic pulmonary arterial hypertension， and two had Eisenmenger's syndrome. All patients underwent a detailed cardiac function assessment before surgery. All six patients underwent double lungtransplantation with VA-ECMO assistance. The duration of ECMO assistance was 2 ～ 7 d， with a median time of 4 d. Two patients used IABP. Three patients developed left heart dysfunction after the surgery. But after effective treatment， all patients' cardiac function recovered during the perioperative period. Postoperative echocardiographic results showed that the relevant indicators of cardiac function of all the patients returned to normal， with statistically significant differences compared to preoperative levels（ P ＜ 0.05）. Conclusion Double lung transplantation is the last treatment option for patients with end-stage pulmonary arterial hypertension. Perioperative circulatory support measures， such as VA-ECMO and IABP， are beneficial for the recovery of cardiac function in such patients. 

Key words:

Pulmonary hypertension , Lung transplantation , Cardiac function , Extracorporeal membrane oxygenation