关键词:

肾移植 , PCP , 细胞免疫

Abstract:

Objective To analyze the correlation between pneumocystis pneumonia infection and cellular immune function. Methods From April 2019 to March 2020, 134 patients with renal transplantation in our department were diagnosed with Pneumocystis pneumonia, 54 of them were diagnosed as pneumocystis pneumonia.The number of CD4 cells was detected to reflect the cellular immune function of patients. The correlation between the incidence rate of pneumocystis pneumonia and cellular immune function was analyzed. Then the CD4 cell count was divided into three groups. The t-test was used to analyze the related indexes of the hospitalization days, the number of oxygen inhalation days, the number of days of pulmonary inflammatory absorption, and so on, and to explore the relationship between CD4 cell count and the prognosis of pneumocystis pneumonia and the prognosis of every two groups. Results Among 134 cases, 53 patients were infected with pneumocystis pneumonia. The prevalence rates of the three groups were 0.237, 0.720 and 0.813，respectively.  According to the grouping, the time of hospitalization,the time of oxygen inhalation and the time of focus absorption were analyzed by t-test. The P values were 0.667, 0.517,0.779, 0.335, 0.863, 0.150, 0.404, 0.139 and 0.405 respectively. The results showed that there was no statistical difference. Conclusion The incidence rate of pneumocystis pneumonia in renal transplant recipients increased withthe decrease of CD4 cell count, but CD4 cell count was not significantly associated with disease prognosis.

Key words:

Kidney transplant, Pneumocystis pneumonia, Cellular immunity