Objective To retrospectively analyze the clinical and prognostic features，and the diagnosis and treatment strategies of denovo autoimmune hepatitis in patients combined with hepatitis B infection and hemochromatosis after liver transplantation in the early postoperative period． Methods In the past 10 years， 1 patient with hemochromatosis combined with hepatitis B who received liver transplantation in our hospital was diagnosed with autoimmune hepatitis in the early postoperative period. New diagnostic criteria of denovo autoimmune hepatitis ：elevated serum IgG ；positive autoimmune antibody ；histological features of chronic hepatitis ；nonhepatitis. According to the specific criteria，6 ～ 7 points may be suspected with，more than 7 points can be diagnosed with autoimmune hepatitis. Results Only one female patient was dignosed with autoimmune hepatitis in 1 month after liver transplantation. γ globulin was 29.4%. IgG was 27.5 g/L. But autoantibody spectrum was normal. Transaminase was normal under the treatment of 12 mg/d of methylprednisolone after one month. Conclusion De novo autoimmune hepatitis after liver transplantation in the early postoperative period is rare. Early diagnosis and rational treatment are keys for improving its prognosis.