Objective To investigate the clinical features of donor-derived drug-resistant Klebsiella pneumoniae infection and to summarize the experience of clinical treatment. Methods The clinical data of 13 patients with postoperative donor-derived drug-resistant Klebsiella pneumoniae infection from January 2016 to October 2017 in three kidney transplant centers of Shanghai were analyzed retrospectively. Results Among the 13 patients，one donor-vascular germiculture was positive，and the graft lavage fluid germicultures of other patients were positive. Five patients who were not treated with avibactam died for widespreadly drug-resistant Klebsiella pneumoniae infection. One patien was cured after combination therapy with ceftazidime-avibactam and carbapenems. As soon as cultures of perirenal fluid drainages were found positive in 6 patients，combination therapies of ceftazidimeavibactam and carbapenems were given，and all of them cured. One patient positive in renal arterial culture was treated with ceftazidime-avibactam. After that his drainage fluid culture became negative and the patient aquired a long-term survival. Conclusion The treatment for donor-derived drug-resistant Klebsiella pneumoniae infection by ceftazidime-avibactam and carbapenems is an effective and without significant side effects. When the graft lavage fluid culture is positive，this treatment should be given in time to ensure the safety of patients.