Objective This study was designed to investigate the impact of various coping modes on thequality of life（QOL）in liver transplant recipients. Methods A total of 141 liver transplant recipients，who were selected through convenient sampling method，were evaluated using the scale of basic conditions，medical coping modes questionnaire（MCMQ）and short-form 36-item questionnaire（SF-36）. MCMQ scores were compared withFeifel norm，while SF-36 scores were compared with Sichuan Province norm，and the correlation between oping modes and QOL was analyzed. Results The scores of confrontation，avoidance and acceptance-resignation

Objective To explore the effect of serum HBsAg-positive expression on tumor recurrence of mouse in immunosuppressive status，thus to provide theoretical and experimental basis for the clinical practice of HBsAg-positive liver graft liver transplantation for patient with end-stage hepatocellular carcimona. Methods The experimental group（Group H）selects 30 hepatitis B virus（HBV）transgenic Balb/c mice，and the control group（Group D）selects 30 normal Balb/c mice. All of the mice were inoculated with H22 tumor cell under the spleenenvelope. After operation all of the mice were given CsA and methyl prednisolone sodium succinate to mimic the immunosuppressive status after liver transplantation. In postoperative 1，2 and 3 weeks，the mice were put todeath. Tumor recurrence rate and tumor load were compared between these two groups. Hematoxylin-Eosin（HE）staining and immunohistochemical detection of proliferating cell nuclear（PCNA），vascular endothelial growth factor （VEGF），inter-cellular adhesion molecule 1（ICAM-1）were performed. Results Tumor recurrence rates of the experimental group after 1，

2，3 weeks were 20%，50% and 80% respectively，with those of the control group were 20%，40% and 70% respectively. Tumor-bearing liver weight of the experimental group after 1，2，3 weeks was（1.04±0.05）g，（1.16±0.06）g and（1.29±0.06）g respectively，with those of the control group were（1.01±0.06）g， （1.13±0.05）g and（1.25±0.08）g respectively . The positive rates of PCNA in the liver tissue of the experimental group after 1，2，3 weeks were 22.20%±5.85%，44.20%±6.07% and 53.40%±7.92% respectively，with those ofthe control group were 22.80%±5.51%，43.60%±6.95% and 56.80%±9.14% respectively. The positive rates of VEGF of the experimental group after 1，2，3 weeks were 20.80%±5.47%，25.90%±5.51% and 37.60%±2.16%respectively，with those of the control group were 17.00%±4.14%，26.70%±6.40% and 37.30%±1.42%respectively. The positive rates of ICAM-1 of the experimental groups after 1，2，3 weeks were 15.40%±3.89%， 23.20%±3.61% and 31.30%±3.47% respectively，with those of the control group were 14.50%±3.41%，22.80%±2.97% and 29.40%±3.69% respectively. There were no statistical differences between these two groups（all P ＞ 0.05）. Conclusion By establishing the animal model of tumor recurrence in immunosuppressive status，we confirm that serum HBsAg-positive expression has no significant effect on tumor recurrence.

Objective To investigate the etiology，clinical presentation，diagnosis and treatment of Intracranial aspergillosis after liver transplantation. Methods Clinical data，diagnosis and treatment of one case with intracranial aspergillosis after liver transplantation were analyzed and correlative literatures were reviewed. Results The patient suffered muscle twitching without obvious cause one month after liver transplantation with clear consciousness. Magnetic resonance image（MRI）of head showed space-occupying lesion with long T1 long T2 signal in the centre and iso T1 short T2 signal around in the right frontal lobe. After enhancing，the lesion showed ring-enhancement with center and low density shadow around no reinforced. Intracranial aspergillosis wasdiagnosed. Then monotherapy of tacrolimus（FK506）was used with withdrawl of mycophenolate mofetil（MMF）and glucocorticoid. The serum FK506 concentration was maintained at a low level，and caspofungin was administratedfor intracranial aspergillosis. The MRI of head showed no obvious changing in the right frontal lobe abscess after two weeks. In order to cure the intracranial infection，the patient underwent resection of the right frontal lobe abscess aftergeneral anesthesia. During the operation，an abscess with tough wall with the size of 1.5 cm×2.0 cm was seen，which was sent to the Department of Pathology after resection. The pathological findings revealed intracranial aspergillosis.After operation，we continued to administrate caspofungin to treat intracranial aspergillosis，and reviewed head CT scan regularly. The patient did not suffer recurrent convulsion and high fever after resection. One month later，head CT scan showed better postoperative brain change and the subcutaneous tissue swelling of the right cranial frontal reduced without other abnormalities. Then the patient was discharged after recovery. Conclusion Dueto intracranial aspergillosis infection，it is difficult to achieve effective inhibitory concentration of antifungal agent.So when the transplant recipient was infected with isolated intracranial aspergillosis，combining local resection with antifungal agent and reducing the dose of anti-rejection drugs may be the ideal treatment.

Objective To introduce the diagnosis and treatment methods for hepatic artery-portal veinfistula after liver transplantation，and to explore the procedure and efficacy of intervention therapy. Methods2 patients suffered hepatic artery-portal vein fistula after liver transplantation caused by percutaneous liverbiopsy，and were treated with microcoil embolization of the fistula after radiological diagnosis in Tianjin first centerhospital. Results In case 1，portal vein width reduced significantly after embolization with blood flow returned to normal，splenomegaly decreased，and ascites reduced. In case 2，hepatic hilar pulsatile mass disappeared afterembolization with restoration of normal blood flow，which proved microcoil embolization was a safe and effectivemethod for hepatic artery-portal vein fistula. Conclusion Once post-transplant hepatic artery-portal vein fistulais diagnosed，interventional embolization is the preferred treatment.