Abstract:

Objective This study focuses on the effect of anti HLA- Ⅱ antibody on kidney function andlong-term survival of kidney transplantation patients. Methods A total number of 107 kidney transplantationpatients from Capital Medical University Affiliated Beijing Friendship Hospital, whose anti HLA class Ⅱ antibodies had been detected to be positive and transplantation operation had been performed in 2007. In 2010-2011, these patients’HLA class Ⅱ antibodies were detected again. In October 2014, these patients were detected for renalfunction and long-term survival. Results The detection results in 2007 showed that 107 kidney transplantationpatients had positive anti HLA- Ⅱ antibody. 19 patients had normal renal function with positive anti HLA- Ⅱantibody in the detection of 2010 and 2011, and normal renal function in 2014. 43 of these patients had normal renal function but their HLA class Ⅱ antibodies turn to be negative in 2010-2011，and they had normal kidney function in 2014. There were 2 of these patients who had normal renal function with negative antibody in 2010-2011, but their renal function reduced in 2014. There were 3 patients who had renal function reduced in 2010-2011 with negative antibody，but their renal function didn’t show downward trend in 2014. A total number of 18 patients lost most renalfunction in 2010-2011 with positive anti HLA- Ⅱ antibody, and lost renal function in 2014. 22 patients lost renalfunction or lost contact 2-3 years after renal transplantation. Conclusion The effects of anti HLA- Ⅱ antibodies on renal allograft vary from different person, and protective antibodies may exist.

摘要：

目的 研究肾移植术后抗人类白细胞抗原（HLA）- Ⅱ类抗体阳性患者与移植肾功能和长期存活。方法 对 2007 年在首都医科大学附属北京友谊医院已检测出抗 HLA- Ⅱ类抗体阳性的肾移植术后107 例患者，于 2010 年和 2011 年再次检测其抗 HLA- Ⅱ类抗体，并在 2014 年 10 月前后进行肾功能和长期存活观察。结果 2007 年检测出 107 例肾移植术后抗 HLA- Ⅱ类抗体阳性患者，其中 19 例患者肾功能正常，2010-2011 年检测仍阳性，2014 年检测肾功能正常。43 例患者肾功能正常，2010-2011 年检测抗HLA- Ⅱ类抗体转阴性，2014 年肾功能正常。2 例患者肾功能正常，2010-2011 年查抗体转阴性，肾功能正常，2014 年肾功能下降。3 例患者肾功能正常，2010-2011 年查抗体转阴性，肾功能下降，2014 年肾功能无再次下降趋势。18 例患者肾功能正常，2010-2011 年查抗 HLA- Ⅱ类抗体阳性，大部分患者肾功能下降，2014 年时肾功能全部下降。22 例患者肾功能正常，2 ～ 3 年后移植肾失功或失联。结论 抗 HLA- Ⅱ类抗体对移植肾功能的影响因人而异，也可能存在保护性抗体。