Abstract:

Objective To analyze the recovery of renal function after kidney transplantationfrom different donors，to explore the difference of short-term effect between donation after cardiac death （DCD）and living-donor（LD）， and to evaluate the feasibility and safety of DCD kidney transplantation and make better use of DCD donor. Methods Participants who underwent kidney transplantation in Organ Transplantation Center，the Department of Urology，Linyi people’s Hospital from December 2017 to January 2023 were selected. According to the source of donors，they were divided into DCD group and LD group.Then the demographic distribution between the two groups was analyzed，and the serum creatinine（Scr）and postoperative complications of the two groups at different time were compared. Results A total number of 70 patients were enrolled，including 50 patients with DCD and 20 patients with LD. Within two weeks after operation，the Scr level decreased to below 200 μmol/L，but the Scr level in DCD group was higher than LD group on day 1 ～ 7 and 9 after operation，the difference was statistically significant（P ＜ 0.05）. Conclusion The effect of DCD renal transplantation is accurate，but there is a certain difference between the short-term renal function recovery after operation compared with LD donor kidney，therefore，preoperative evaluation should be strengthened. 

Key words:

End stage renal disease , Kidney transplantation , Donation after cardiac death , Living donor, Transplantation effect

摘要：

目的 探讨心脏死亡器官捐献（donation after cardiac death，DCD）供肾与亲属活体捐献（livingdonor，LD）供肾移植术后短期效果的差异，评估 DCD 供肾移植的可行性及安全性，以便更好地利用 DCD 来源供肾。 方法 选取 2017 年 12 月至 2023 年 1 月在临沂市人民医院泌尿外科行肾脏移植术后患者，根据供者的来源分为 DCD 组和 LD 组。收集两组的临床资料，并比较两组术后不同时间血肌酐变化及术后并发症等发生情况。 结果 共纳入患者 70 例，其中 DCD 为 50 例，LD 为 20 例。两组均恢复顺利，术后 2 周内血肌酐均降至 200 μmol/L 以下，手术时间、住院时间及术后并发症发生率均差异无统计学意义。但 DCD 组术后 2 周内血肌酐水平要高于 LD 组，其中第 1 ～ 7 天及第 9 天两组血肌酐水平比较差异有统计学意义（P ＜ 0.05）。 结论 DCD 肾移植效果确切，但在术后短期肾功能恢复与 LD 供肾存在一定的差异，需要加强术前评估。

关键词: 终末期肾病 , , 肾移植 , , 心脏死亡器官捐献 , , 亲属活体捐献 , , 移植效果