Abstract:

Objective To analyze the correlation between pneumocystis pneumonia infection and cellular immune function. Methods From April 2019 to March 2020, 134 patients with renal transplantation in our department were diagnosed with Pneumocystis pneumonia, 54 of them were diagnosed as pneumocystis pneumonia.The number of CD4 cells was detected to reflect the cellular immune function of patients. The correlation between the incidence rate of pneumocystis pneumonia and cellular immune function was analyzed. Then the CD4 cell count was divided into three groups. The t-test was used to analyze the related indexes of the hospitalization days, the number of oxygen inhalation days, the number of days of pulmonary inflammatory absorption, and so on, and to explore the relationship between CD4 cell count and the prognosis of pneumocystis pneumonia and the prognosis of every two groups. Results Among 134 cases, 53 patients were infected with pneumocystis pneumonia. The prevalence rates of the three groups were 0.237, 0.720 and 0.813，respectively.  According to the grouping, the time of hospitalization,the time of oxygen inhalation and the time of focus absorption were analyzed by t-test. The P values were 0.667, 0.517,0.779, 0.335, 0.863, 0.150, 0.404, 0.139 and 0.405 respectively. The results showed that there was no statistical difference. Conclusion The incidence rate of pneumocystis pneumonia in renal transplant recipients increased withthe decrease of CD4 cell count, but CD4 cell count was not significantly associated with disease prognosis.

Key words:

Kidney transplant, Pneumocystis pneumonia, Cellular immunity

摘要：

目的 分析肺孢子菌肺炎感染与 CD4 细胞计数的相关性。方法 对武汉大学人民医院器官移植科 2019 年 4 月至 2020 年 3 月收治的 134 例肾移植术后 1 年内患者，其中 54 例患者确诊感染肺孢子菌肺炎，检测 CD4 细胞数量。分析肺孢子菌肺炎发病率与 CD4 细胞计数是否具有相关性，再根据 CD4 细胞计数分成 3 组，以 t 检验分别分析两组患者的住院天数、吸氧天数、肺部炎症吸收天数等相关指标，探究CD4 细胞计数与肺孢子菌肺炎转归与预后之间的关系。结果 134 例病例中有 53 例患者感染肺孢子菌肺炎，3 组患病率分别 0.237、0.720、0.813。根据分组分别用住院时间、吸氧时间、病灶吸收时间两两进行 t 检验，P 值分别为 0.667、0.517、0.779、0.335、0.863、0.150、0.404、0.139、0.405。结果显示均无统计学差异。结论 在肾移植患者术后，肺孢子菌肺炎的发病率随着 CD4 细胞计数的减少而上升，但 CD4 细胞计数与疾病预后没有明显关联。

关键词:

肾移植 , PCP , 细胞免疫