Abstract:

Objective To clear the pathological characteristics of various complications following liver transplantation in a series of samples. Methods The clinical data of 34 patients were collected，who underwent allogeneic liver transplantation between July 2011 to August 2017 in Liver transplantation center，The First Affiliated Hospital of Zhengzhou University. The biopsy tissues were stained by HE method． Masson trichrom staining and immunohistochemical staining were performed in part of samples．Histological patterns were observed，and complications were determined. Results A total number of 33 liver-transplant patients were studied，including 28 male and 5 female. The average age was 42.3±12.9. One patient underwent the liver biopsy for two times. The diagnoses were as following ：HBV-related hepatocirrhosis in 13 cases，HCV-related hepatocirrhosis in 2 cases， alcoholic liver cirrhosis in 4 cases，cryptogenic cirrhosis in 1 case，hepatitis B with hepatocellular carcinoma in 8 cases，hepatolenticular degeneration in 2 cases，primary biliary cirrhosis in 1 case，biliary atresia in 1 case and congenital hepatic fibrosis in 1 case. Among of them，ischemia-reperfusion injury（2 episodes，5.9%），Acute cellular rejection（15 episodes，44.1%），biliary tract complication（4 episodes，11.8%），drug toxicity（12 episodes，35.3%） and primary graft non-function（1 episodes，2.9%）were found. Conclusion Liver biopsy plays an important role in the diagnosis of the complications following liver transplantation.

摘要：

目的 探讨肝移植术后各种并发症的病理学特点。方法 回顾性分析 2011 年 7 月-2017 年 8 月 郑州大学第一附属医院肝移植中心 34 例次进行同种异体肝移植患者的临床资料。常规苏木素 - 伊红（HE） 染色，部分病例做 Masson 三色染色、网状纤维组织化学染色及免疫组化染色，对其术后并发症的发生率进 行分析和病理学观察。结果 共纳入 33 例肝移植患者，其中行肝穿刺活检 2 次的 1 例 ；男性 28 例，女性 5 例，平均年龄（42.3±12.9）岁；原发病为乙型肝炎肝硬化 13 例，丙型肝炎肝硬化 2 例，酒精性肝硬化 4 例， 隐源性肝硬化 1 例，乙型肝炎伴肝细胞癌 8 例，肝豆状核变性 2 例，原发性胆汁性肝硬化 1 例，胆道闭锁 1 例，先天性肝纤维化 1 例。34 例次移植肝活检中，缺血 / 再灌注损伤 2 例次（5.9%），急性排斥反应（AR） 15 例次（44.1%），胆道并发症 4 例次（11.8%），药物性肝损伤 12 例次（35.3%），原发性移植物无功能 1 例次（2.9%）。结论 移植术后各种并发症都存在相对特异的病理学特征，肝穿刺活检对肝移植术后并发 症的诊断具有重要价值。