Objective To investigate the relationship between the CD4+T lymphocytes ATP level inperipheral blood and infections after liver transplantation（LT）. Methods Total 142 samples were collected from101 patients' peripheral blood post-LT. CD4+T lymphocytes ATP value was analyzed by ImmuKnow immune cellfunction assay kits. According to the occurrence of infection and immune responses conditions，the patients post-LTwere divided into different groups and then the relationship between the level of CD4+T cells ATP and infection wasanalyzed. Results According to the clinical state，the patients were divided into infection group and non-infectiongroup. CD4+T lymphocytes ATP value was significantly different between the two groups（P ＝ 0.001），which were236.0（41.0～512.0）μg/L and 371.5（9.0～1000.0）μg/L respectively. On the other hand，the patients post-LT weredivided into low immune response group，normal immune response group and high immune response according to the ATP levels of CD4+T lymphocytes in peripheral blood. The infection rates were 25.0%，13.6% and 0 in these groupsrespectively，which had significant statistic difference among three groups（P ＝ 0.003）. Conclusion The ATP value of CD4+T lymphocyte in peripheral blood was significantly correlated with occurrence of infection post-LT whichwould be helpful to conduct clinical therapy.

Liver transplantation, Infection, CD4+T lymphocyte, ATP

目的 探讨外周血 CD4+T 淋巴细胞内三磷酸腺苷（ATP）水平与肝移植术后感染之间的关系。方法 采集肝移植术后患者外周血样本 142 例次，应用 ImmuKnow 免疫细胞功能检测试剂盒检测 ATP。根据患者肝移植术后是否发生感染及不同的免疫应答状态分组，分析 CD4+T 淋巴细胞 ATP 水平与肝移植术后感染的关系。结果 根据患者临床状态将患者分为感染组和非感染组，其 ATP 值分别为 236.0（41.0～512.0）μg/L 和 371.5（9.0～1000.0）μg/L，两组比较差异有统计学意义（P ＝ 0.001）。根据患者外周血CD4+T 淋巴细胞 ATP 水平将患者分为低免疫应答组、正常免疫应答组和高免疫应答组，其肝移植术后感染的发生率分别为 25.0%、13.6% 和 0，各组间移植术后感染的发生率比较差异有统计学意义（P ＝ 0.003）。结论 外周血 CD4+T 淋巴细胞 ATP 值与肝移植术后感染间具有良好的相关性，有利于指导临床治疗。

肝移植 , 感染 , CD4+T 淋巴细胞 , 三磷酸腺苷