Practical Journal of Organ Transplantation(Electronic Version) ›› 2013, Vol. 1 ›› Issue (1): 13-16.

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Analysis of the outcome of 22 cases with donation after cardiac death liver transplantation

YUE Yang1，ZANG Yun-jin1，WU Feng-dong1，REN Xiu-jun1，GUAN Zhao-jie1，LI Wei1，CHEN Xin-guo1，SHEN Zhong-yang2.   

  1. 1. Institute of Organ Transplantation，Armed Police General Hospital，Beijing 100039，China ；
    2. Tianjin First Center Hospital，Tianjin 300192，China
  • Online:2013-01-20 Published:2021-04-15

心脏死亡器官捐献供体肝脏移植22例临床应用效果分析

岳扬 1 ，臧运金 1 ，吴凤东 1 ，任秀昀 1 ，关兆杰 1 ，李威 1 ，陈新国 1 ，沈中阳 2   

  1. 1. 武警总医院器官移植研究所，北京 100039 ；   2. 天津市第一中心医院，天津 300192
  • 基金资助:
    卫生部公益性行业基金资助项目（20080200）

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Abstract:

Objective To summarize the experience of liver transplantation with donor after cardiac death free-donated liver. Methods There were 22 patients with end stage liver disease patients underwent orthotopic liver transplantation（OLT） with donor liver of after cardiac death patients from March 2008 to December 2012 at our institute. The age of donors was from 2 to 53 years old.The  average of warm-ischemia time was 18 minutes，and the cold-ischemia time was 7.5 hours. All recipients received triple immunosuppression including tacrolimus（FK506），mycoplenolate mofetil and methyprednisolone post-transplantation. The liver function and FK506 blood level were detected routinely. Results All 22 patients were underwent liver transplantation successfully，one case of primary transplantation liver nonfunction post operation happened ；2 died during peroperative period，and 20 cases recovered smoothly. Patients were followed from 2 months to 40 months，one patient died after 16 months for cancer recurrence，the liver function of other patients recover successfully，prognosis were well and none suffered surgical complications.Conclusion The results revealed that liver function recovers on time after transplantation using donor after cardiac
death free-donated liver，while there is no obvious post operation complications happening.

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摘要：

目的 总结接受心脏死亡器官捐献（DCD）供体肝脏移植的终末期肝病患者的治疗经验及效果。方法 回顾性分析 2008 年 3 月至 2012 年 12 月本院行原位肝脏移植手术的终末期肝病患者 22 例，均接受DCD 供体，供者年龄 2～53 岁，均为中国Ⅲ类可控性 DCD，车祸致严重脑损伤导致脑死亡 13 例，脑部神经系统疾病导致脑死亡 9 例；热缺血时间 13～28 分钟，平均 18 分钟；冷缺血时间 5～12 小时，平均 7.5 小时。所有受者接受肝移植后早期均采用三联免疫抑制方案（他克莫司 + 吗替麦考酚酯 + 类固醇激素），程序化复查移植肝脏功能及血药浓度，记录移植肝功能的恢复、并发症发生及存活情况。结果 22 例患者均顺利接受 DCD 供肝移植，术后移植肝原发无功能 1 例；围手术期死亡 2 例，20 例患者恢复顺利。随访 2～40 个月，1 例患者于术后 16 个月因肿瘤复发而死亡，其他患者术后肝功能恢复顺利，预后良好，未出现手术相关并发症。结论 DCD 供肝肝移植后肝功能多可顺利恢复，术后并发症发生率无明显增加。

关键词:

Practical Journal of Organ Transplantation(Electronic Version)
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