Abstract:

Objective To analyze the long-term results after simultaneous pancreas-kidney transplantation at a single center． Methods A retrospective analysis of the survival rates of 58 recipients and transplanted organsfrom May 2010 to December 2019 was conducted in the Department of Organ Transplantation，923thHospital of PLA Joint Logistic Support Force．The causes of death and loss of graft function were analyzed.Results Recipient’s survival rates in the 1，3，5 and 8 years were 98.28%，98.28%，92.24% and 89.99%，respectively．The 1，3，5 and 8 year survival rates of pancreas grafts were 86.21%，84.48%，78.40% and 76.16%，and that of kidney grafts were 98.28%，98.28%，82.83% and 80.60%，respectively．The survival rates after bladder drainage（BD）procedure at 1，3，5 and 8 year was 96.15%、96.15%、 86.73% and 86.73% and the survival rates of enteric drainage（ED）procedure was 100%，100%，96.67% and 93.33% （P ＝ 0.187）. Conclusion Simultaneous pancreas-kidney transplantation has a good long-term effect on end-stage diabetic nephropathy. Surgical complications are the main factors affecting the long-term outcomes. ED procedure may have a betterlong-termprognosis. Infection，rejectionand recipient death are also important factors for graft functionloss.

Key words:

Diabetes mellitus , End-stage renal disease , Kidney transplantation, Pancreastransplantation, Simultaneous pancreas-kidney transplantation

摘要：

目的 回顾性分析单中心 58 例胰肾联合移植的远期疗效及相关影响因素。 方法 回顾性分析中国人民解放军联勤保障部队第九二三医院器官移植科 2010 年 5 月至 2019 年 12 月完成的 58 例胰肾联合移植手术受者和移植器官的存活率，并分析移植器官功能丢失和受者死亡原因。结果 1、3、5、8 年受者生存率分别为 98.28%、98.28%、92.24%、89.99%，移植胰腺存活率分别为 86.21%、84.48%、78.40%、76.16%，移植肾存活率分别为 98.28%、98.28%、82.83%、80.60%，胰液膀胱引流（bladder drainage，BD）术式 1、3、5、8 年生存率为 96.15%、96.15%、86.73%、86.73%，胰液空肠引流（enteric drainage，ED）术式 1、3、5、8 年 生存率为 100%、100%、96.67%、93.33%（P ＝ 0.187）。 结论 胰肾联合移植对于终末期糖尿病肾病的远期疗效较好，ED 术式可能会有更好的长期预后，外科并发症是影响胰肾联合移植远期疗效的主要因素，器官排斥反应、感染和受者带功死亡也是移植器官功能丢失的重要因素。 

关键词:

糖尿病 , 终末期肾病 , 肾移植 , 胰腺移植 , 胰肾联合移植