Abstract:

Objective To investigate the safety and efficacy of islet transplantation after failed pancreas transplantation， and to summarize the literature experience. Methods The clinical data of 3 patients with islettransplantation after failed pancreas transplantation in the first Affiliated Hospital of Sun Yat-sen University wereretrospectively analyzed and followed up for 6 months.Results In the 3 patients who received islet transplantation afterfailed pancreas transplantation， the islet function was good after operation， the level of fasting C-peptide was significantly improved compared with that before surgery. All patients stopped using exogenous insulin or reduced the dosage by morethan 2/3， and their blood glucose was stable. Conclusion islet transplantation after failed pancreas transplantation canbe a remedial treatment for diabetes mellitus with high efficacy and safety. 

Key words:

Islet transplantation； , Pancreas transplantation； , Diabetes mellitus

摘要：

目的 探讨胰岛移植治疗胰腺移植术后移植物失功的安全性及有效性，并总结文献经验。方法 回顾性分析中山大学附属第一医院 3 例胰岛移植治疗胰腺移植术后移植物失功的临床资料，并随访 6 个月进行总结分析。结果 胰腺移植术后移植物失功接受胰岛移植的 3 例患者术后胰岛功能良好，空腹 C 肽水平均较术前明显提升，出院前 1 例实现停用外源性胰岛素，其余 2 例胰岛素用量减少 2/3 以上，且均血糖平稳。结论 对胰腺移植术后移植物失功的患者实施胰岛移植可以有效地补救性治疗糖尿病，且安全性高。

关键词:

胰岛移植 , 胰腺移植 , 糖尿病