Objective To investigate the effect and intervention strategy of adopting elderly donor liver on graft function and survival rate of recipients after liver transplantation. Methods The patients who underwent liver transplantation from January 2016 to June 2017 were paired selected and divided into two groups based on the age of donors ≥ or ＜ 60 years old ：the elderly donor（ED，n ＝ 74）group and the non-elderly donor（NED，n ＝ 74） group. The recovery of liver function，complications，graft and recipient survival rate were compared. Results The incidence of early allograft dysfunction and biliary complications in the ED group were 47.3% and 21.6%， significantly higher than those in the NED group which were 28.4% and 9.5%（P ＝ 0.018，P ＝ 0.041）. The survival rate of grafts was significantly lower in the NED group compared with ED group（P ＝ 0.023）. In ED group， the incidence of early allograft dysfunction was 70.6% in patients with cold ischemia time ＞ 12 h，significantly higher than 40.4% in patients with cold ischemia time ＜ 12 h（P ＝ 0.003）.Conclusion The application of elderlydonor liver will influence the early functional recovery and survival rate of the graft. Shortening CIT could significantly reduce the incidence of early allograft dysfunction and improve the prognosis of the recipient.

目的 研究高龄供肝对肝移植术后移植物功能及受者生存率的影响及其干预策略。方法 根 据供者年龄≥或＜ 60 岁 1 ：1 配对选取 2016 年 1 月—2017 年 6 月期间行肝移植手术患者为研究对象， 分为高龄供者（elderly donor，ED，n ＝ 74）组和非高龄供者（non-elderly donor，NED，n ＝ 74）组。比较 分析受者肝功能恢复情况、并发症、移植物及受者生存率。结果 ED 组移植物早期功能不全发生率为 47.3%，显著高于 NED 组的 28.4%（P ＝ 0.018）；ED 组胆道并发症发生率为 21.6%，显著高于 NED 组 的 9.5% （P ＝ 0.041）；ED 组移植物存活率显著低于 NED 组（P ＝ 0.023）。ED 组冷缺血时间＞ 12 h 者移植物早期 功能不全发生率显著高于＜ 12 h 者（70.6% 比 40.4%，P ＝ 0.003）。结论 高龄供肝的使用会影响移植物早 期功能恢复及其 1 年存活率，缩短冷缺血时间可以显著降低 EAD 的发生率，改善受者预后。