Abstract:

Objective To investigate the prognosis and management strategies of renal transplant recipientswith end-stage diabetic nephropathy. Methods The clinical data of 276 recipients of deceased donor kidneytransplantation after the death of citizens in our hospital from January 2015 to January 2018 were retrospectively analyzed. Twenty patients with diabetic nephropathy were defined as the experimental group and 256 patients withnon-diabetic nephropathy were defined as the control group. The delayed recovery of renal function（DGF），infection，rejection and the survival of transplant recipients and kidneys during perioperative period of kidney transplantation were compared between the two groups. Results The incidence of DGF，infection and rejection in the experimentalgroup was higher than that in the control group during the perioperative period，but there was no significant differencebetween the two groups. In addition，there was no significant difference in the survival rate of transplant recipients and kidneys in the two groups at 1，2 and 3 years after transplantation. Conclusion End-stage diabetic nephropathyrecipients are likely to suffer from infection，DGF and rejection during perioperative period. Perioperative managementand long-term scientific and comprehensive follow-up should be strengthened. There is no difference in 3 years survival rate between diabetic nephropathy recipients and non-diabetic nephropathy recipients.

Key words: Diabetic nephropathy, Kidney transplantation

摘要：

目的 探讨终末期糖尿病肾病肾移植受者的预后及管理策略。方法 回顾性分析本院 2015 年1 月—2018 年 1 月 276 例公民逝世后器官捐献肾移植受者的临床资料，将原发病为糖尿病肾病的 20 例受者作为试验组，将原发病为非糖尿病肾病的 256 例受者作为对照组，比较两组肾移植围术期移植肾功能延迟恢复（delayed renal graft function，DGF）、感染、排斥反应以及移植受者和移植肾存活情况。结果 试验组在围术期 DGF、感染和排斥反应发生率等均较对照组增高，但两组比较无统计学差异。此外，两组移植后 1 年、2 年、3 年的移植受者和移植肾存活率均无统计学差异。结论 终末期糖尿病肾病肾移植受者在围术期易出现感染、DGF 及排斥反应，应加强对其围术期的管理，而对其行科学全面的随访，3 年内的生存率与非糖尿病肾病肾移植受者可无差异。

关键词: 糖尿病肾病 , 肾移植